Splines

There is a readme text posted on line (link below) that originated from Icon some time ago: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM readme.txt ... https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM https://nonmem.iconplc.com/nonmem/constrained%20longitudinal%20spline/readme .txt 1. https://webcache.googleusercontent.com/search?q=cache:xWJ5Iy0lqgsJ: https:// nonmem.iconplc.com/nonmem/constrained%2520longitudinal%2520spline/readme.txt +&cd=6&hl=en&ct=clnk&gl=us Cached Nov 18, 1997 - The longitudinal splines are constrained to exhibit (i) decreasing tail (ii) ... random effects denoted ETAj in NONMEM, where ETAj is distributed ... You've visited this page 5 times. Last visit: 1/15/19 When I tried to run the code for a single dose I got an error message and since the code referenced Icon, I thought that I would ask you before sending it to NMusers. The control and data are attached. The error message was that the characters in error were: Pack $268 SUBROUTINES EEROR WHILE OPENING OR COPYING USED SUPPLIED SUBROUTINE SDSPLINE_DAT.csv Description: MS-Excel spreadsheet TEST.ctl Description: Binary data