Splines
There is a readme text posted on line (link below) that originated from Icon
some time ago:
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac
t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm
em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t
xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM readme.txt ...
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac
t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm
em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t
xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac
t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm
em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t
xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM
https://nonmem.iconplc.com/nonmem/constrained%20longitudinal%20spline/readme
.txt
1.
https://webcache.googleusercontent.com/search?q=cache:xWJ5Iy0lqgsJ: https://
nonmem.iconplc.com/nonmem/constrained%2520longitudinal%2520spline/readme.txt
+&cd=6&hl=en&ct=clnk&gl=us Cached
Nov 18, 1997 - The longitudinal splines are constrained to exhibit (i)
decreasing tail (ii) ... random effects denoted ETAj in NONMEM, where ETAj
is distributed ...
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When I tried to run the code for a single dose I got an error message and
since the code referenced Icon, I thought that I would ask you before
sending it to NMusers.
The control and data are attached. The error message was that the
characters in error were:
Pack
$268 SUBROUTINES EEROR WHILE OPENING OR COPYING USED SUPPLIED SUBROUTINE
SDSPLINE_DAT.csv
Description:
MS-Excel spreadsheet
TEST.ctl
Description:
Binary data