Hello,
is there any possiblity to set initial values for the PHIs for each individual
in the Bayesian methods?
I have a rather complex system with local minimas in the ETA distribution, thus
I would like to start the subjects PHIs at values derived by eye fitting or
individual fitting using seperate models.
Any suggestions are highly welcome
Sven
________________________________
Abbott GmbH & Co. KG
Sitz der Gesellschaft: Wiesbaden - Registergericht: AG Wiesbaden HRA 4888
Pers?nlich haftende Gesellschafterin: Abbott Management GmbH
Sitz der pers?nlich haftenden Gesellschafterin: Wiesbaden - Registergericht: AG
Wiesbaden HRB 12889
Gesch?ftsf?hrer: Alexander W?rfel, Dr. Friedrich Richter, Matthias D?schner ,
Kathy Vinchkoski Turner
Vorsitzender des Aufsichtsrats: Brian Blaser
Set initial values for PHIs
Sven:
You cannot easily bring in individual phi values externally. But, suitable
optimal phi values can be supplied to the BAYES method if you perform an ITS
analysis just before that. For example,
$EST METHOD=ITS INTERACTION NITER=0 (plus additional options)
$EST METHOD=BAYES INTERACTION NBURN=4000 NITER=10000 (plus additional options)
If you want ITS to also provide suitable starting values for thetas, omegas and
sigmas as well:
$EST METHOD=ITS INTERACTION NITER=30 (plus additional options)
$EST METHOD=BAYES INTERACTION NBURN=4000 NITER=10000 (plus additional options)
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics, R&D
ICON Development Solutions
7740 Milestone Parkway
Suite 150
Hanover, MD 21076
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: http://www.iconplc.com/
Quoted reply history
________________________________
From: [email protected] [mailto:[email protected]] On
Behalf Of Mensing, Sven
Sent: Tuesday, March 20, 2012 9:15 AM
To: [email protected]
Subject: [NMusers] Set initial values for PHIs
Hello,
is there any possiblity to set initial values for the PHIs for each individual
in the Bayesian methods?
I have a rather complex system with local minimas in the ETA distribution, thus
I would like to start the subjects PHIs at values derived by eye fitting or
individual fitting using seperate models.
Any suggestions are highly welcome
Sven
________________________________
Abbott GmbH & Co. KG
Sitz der Gesellschaft: Wiesbaden - Registergericht: AG Wiesbaden HRA 4888
Persönlich haftende Gesellschafterin: Abbott Management GmbH
Sitz der persönlich haftenden Gesellschafterin: Wiesbaden - Registergericht: AG
Wiesbaden HRB 12889
Geschäftsführer: Alexander Würfel, Dr. Friedrich Richter, Matthias Däschner ,
Kathy Vinchkoski Turner
Vorsitzender des Aufsichtsrats: Brian Blaser