Dear NM-Users,
Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday
evening, 30JUL2024.
I was able to get there over the weekend prior to visit him and his family.
During his wakeful moments we had some good scientific discussions.
We talked a lot about NONMEM and how its functionality and utility has expanded
since he retired. He was pleased to hear about the changes.
He was surrounded by family for the days leading up to the end. They were all
appreciative that I was able to get there and tell him (and them) how much he
meant to all of us and the impact he had on our careers.
I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay,
"I am forever grateful for the positive impact that Tom had on my life and
career, not to mention the tremendous, although often underappreciated,
contributions he made to the disciplines of clinical pharmacology and
pharmacometrics. His humble brilliance will be missed and fondly remembered."
Steve Riley
Sad news about Dr. Ludden
Dear All
I am very saddened to hear this news. Tom Ludden was one of the nicest and
smartest people that I have ever known. He was a gentle giant in our field and
I will miss him.
Best
Diane
Quoted reply history
From: [email protected] <[email protected]> On Behalf Of
Riley, Steve
Sent: Friday, August 2, 2024 2:41 PM
To: [email protected]
Subject: [External email][NMusers] Sad news about Dr. Ludden
CAUTION: This email originated from outside the organization. Do not click
links or open attachments unless you recognize the sender and know the content
is safe.
Dear NM-Users,
Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday
evening, 30JUL2024.
I was able to get there over the weekend prior to visit him and his family.
During his wakeful moments we had some good scientific discussions.
We talked a lot about NONMEM and how its functionality and utility has expanded
since he retired. He was pleased to hear about the changes.
He was surrounded by family for the days leading up to the end. They were all
appreciative that I was able to get there and tell him (and them) how much he
meant to all of us and the impact he had on our careers.
I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay,
"I am forever grateful for the positive impact that Tom had on my life and
career, not to mention the tremendous, although often underappreciated,
contributions he made to the disciplines of clinical pharmacology and
pharmacometrics. His humble brilliance will be missed and fondly remembered."
Steve Riley
I second everything Steve, and Mark, and Diane said. All of us who were blessed to work alongside him will forever remember him with fondness and gratitude. And let's not forget that he was the only one who Stuart Beal trusted to take care of NONMEM and bring it forward into 21st century.
Katya
Quoted reply history
On 8/2/2024 3:55 PM, Diane Mould wrote:
> Dear All
>
> I am very saddened to hear this news. Tom Ludden was one of the nicest and smartest people that I have ever known. He was a gentle giant in our field and I will miss him.
>
> Best
>
> Diane
>
> *From:* [email protected] < [email protected] > *On Behalf Of *Riley, Steve
>
> *Sent:* Friday, August 2, 2024 2:41 PM
> *To:* [email protected]
> *Subject:* [External email][NMusers] Sad news about Dr. Ludden
>
> *CAUTION:*This email originated from outside the organization. Do not click links or open attachments unless you recognize the sender and know the content is safe.
>
> Dear NM-Users,
>
> Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday evening, 30JUL2024.
>
> I was able to get there over the weekend prior to visit him and his family.
>
> During his wakeful moments we had some good scientific discussions.
>
> We talked a lot about NONMEM and how its functionality and utility has expanded since he retired. He was pleased to hear about the changes.
>
> He was surrounded by family for the days leading up to the end. They were all appreciative that I was able to get there and tell him (and them) how much he meant to all of us and the impact he had on our careers.
>
> I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay, “I am forever grateful for the positive impact that Tom had on my life and career, not to mention the tremendous, although often underappreciated, contributions he made to the disciplines of clinical pharmacology and pharmacometrics. His humble brilliance will be missed and fondly remembered.”
>
> Steve Riley
Dear All:
In Dr. Ludden we lost an excellent scientist who helped to revolutionize and advance clinical pharmacokinetics, pharmacometrics, clinical pharmacology, and drug development. I’m indebted to him for the impact he made on my life as a pharmacometrician, clinical pharmacologist, and drug developer while working with him at the FDA. He started the Pharmacometrics Staff Unit which became Pharmacometrics Division in later years.
May his soul rest in peace.
Sincerely,
Ene.
Sent from
Mail
for Windows
Quoted reply history
From:
Diane Mould
Sent:
Friday, August 2, 2024 4:03 PM
To:
Riley, Steve
;
[email protected]
Subject:
RE: [External email][NMusers] Sad news about Dr. Ludden
Dear All
I am very saddened to hear this news. Tom Ludden was one of the nicest and smartest people that I have ever known. He was a gentle giant in our field and I will miss him.
Best
Diane
From:
[email protected]
<
[email protected]
>
On Behalf Of
Riley, Steve
Sent:
Friday, August 2, 2024 2:41 PM
To:
[email protected]
Subject:
[External email][NMusers] Sad news about Dr. Ludden
CAUTION:
This email originated from outside the organization. Do not click links or open attachments unless you recognize the sender and know the content is safe.
Dear NM-Users,
Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday evening, 30JUL2024. I was able to get there over the weekend prior to visit him and his family.
During his wakeful moments we had some good scientific discussions.
We talked a lot about NONMEM and how its functionality and utility has expanded since he retired. He was pleased to hear about the changes. He was surrounded by family for the days leading up to the end. They were all appreciative that I was able to get there and tell him (and them) how much he meant to all of us and the impact he had on our careers.
I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay, “I am forever grateful for the positive impact that Tom had on my life and career, not to mention the tremendous, although often underappreciated, contributions he made to the disciplines of clinical pharmacology and pharmacometrics. His humble brilliance will be missed and fondly remembered.”
Steve Riley
Very sorry to hear this news.
He was a patient, kind and great teacher who went out of his way for his
students!
May he rest in peace
Sujatha
Quoted reply history
On Aug 2, 2024, at 4:25 PM, Ekaterina Gibiansky <[email protected]>
wrote:
I second everything Steve, and Mark, and Diane said. All of us who were blessed
to work alongside him will forever remember him with fondness and gratitude.
And let's not forget that he was the only one who Stuart Beal trusted to take
care of NONMEM and bring it forward into 21st century.
Katya
On 8/2/2024 3:55 PM, Diane Mould wrote:
Dear All
I am very saddened to hear this news. Tom Ludden was one of the nicest and
smartest people that I have ever known. He was a gentle giant in our field and
I will miss him.
Best
Diane
From: [email protected]<mailto:[email protected]>
<[email protected]><mailto:[email protected]> On Behalf
Of Riley, Steve
Sent: Friday, August 2, 2024 2:41 PM
To: [email protected]<mailto:[email protected]>
Subject: [External email][NMusers] Sad news about Dr. Ludden
CAUTION: This email originated from outside the organization. Do not click
links or open attachments unless you recognize the sender and know the content
is safe.
Dear NM-Users,
Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday
evening, 30JUL2024.
I was able to get there over the weekend prior to visit him and his family.
During his wakeful moments we had some good scientific discussions.
We talked a lot about NONMEM and how its functionality and utility has expanded
since he retired. He was pleased to hear about the changes.
He was surrounded by family for the days leading up to the end. They were all
appreciative that I was able to get there and tell him (and them) how much he
meant to all of us and the impact he had on our careers.
I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay,
“I am forever grateful for the positive impact that Tom had on my life and
career, not to mention the tremendous, although often underappreciated,
contributions he made to the disciplines of clinical pharmacology and
pharmacometrics. His humble brilliance will be missed and fondly remembered.”
Steve Riley
Dear Nmusers:
The PK/PD scientists here at ICON express our sincere condolences on the
passing of Tom Ludden. As mentioned by several already, Tom was very
instrumental in transitioning the NONMEM software development from the labs of
Beal, Sheiner, and Boeckmann at UCSF, to Globomax, then to ICON. The
development team at ICON was greatly aided in adding additional features from
NONMEM VI to NONMEM 7 with his expert direction and his connections with many
in the PK/PD modeling and population analysis community offering their inputs
regarding desired features (and fixing a few bugs!). Tom continued with ICON
all the way through the development of NONMEM 7.2 before his retirement in
Spring 2011, and oversaw the incorporation of dynamic memory allocation, as
well as parallel computing that were first incorporated in that version, which
was a significant milestone in the performance of NONMEM. In a retirement
speech some years ago Tom expressed that his greatest desire was that he was
useful to the PK/PD and pharmacometrics field. He certainly accomplished this
in a way few of us can ever hope to achieve.
Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
731 Arbor way, suite 100
Blue Bell, PA 19422
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected]<mailto:[email protected]>
http://www.iconplc.com/
Public
Dear All,
I am extremely saddened to hear this news. As mentioned by Ene, Dr. Tom Ludden
was one of the pioneers in advancing pharmacometrics along with Dr. Beal and
Dr. Sheiner promoting its value and impact in drug discovery and development as
well as acceptance by the FDA. He provided invaluable scientific advice and
trained numerous scientists in pharmacometrics. He was a real gentle soul and
it was truly a privilege to have known him and be tutored by him.
May his soul rest in peace.
Sincerely,
Bela
Quoted reply history
From: [email protected] <[email protected]> On Behalf Of
ENE ETTE
Sent: Friday, August 2, 2024 5:30 PM
To: Diane Mould <[email protected]>; Riley, Steve <[email protected]>;
[email protected]
Subject: RE: [External email][NMusers] Sad news about Dr. Ludden
Some people who received this message don't often get email from
[email protected]<mailto:[email protected]>. Learn why this is
https://aka.ms/LearnAboutSenderIdentification
EXTERNAL EMAIL– Use caution with any links or file attachments.
Dear All:
In Dr. Ludden we lost an excellent scientist who helped to revolutionize and
advance clinical pharmacokinetics, pharmacometrics, clinical pharmacology, and
drug development. I’m indebted to him for the impact he made on my life as a
pharmacometrician, clinical pharmacologist, and drug developer while working
with him at the FDA. He started the Pharmacometrics Staff Unit which became
Pharmacometrics Division in later years.
May his soul rest in peace.
Sincerely,
Ene.
Sent from https://go.microsoft.com/fwlink/?LinkId=550986 for Windows
From: Diane Mould<mailto:[email protected]>
Sent: Friday, August 2, 2024 4:03 PM
To: Riley, Steve<mailto:[email protected]>;
[email protected]<mailto:[email protected]>
Subject: RE: [External email][NMusers] Sad news about Dr. Ludden
Dear All
I am very saddened to hear this news. Tom Ludden was one of the nicest and
smartest people that I have ever known. He was a gentle giant in our field and
I will miss him.
Best
Diane
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> On Behalf
Of Riley, Steve
Sent: Friday, August 2, 2024 2:41 PM
To: [email protected]<mailto:[email protected]>
Subject: [External email][NMusers] Sad news about Dr. Ludden
CAUTION: This email originated from outside the organization. Do not click
links or open attachments unless you recognize the sender and know the content
is safe.
Dear NM-Users,
Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday
evening, 30JUL2024.
I was able to get there over the weekend prior to visit him and his family.
During his wakeful moments we had some good scientific discussions.
We talked a lot about NONMEM and how its functionality and utility has expanded
since he retired. He was pleased to hear about the changes.
He was surrounded by family for the days leading up to the end. They were all
appreciative that I was able to get there and tell him (and them) how much he
meant to all of us and the impact he had on our careers.
I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay,
“I am forever grateful for the positive impact that Tom had on my life and
career, not to mention the tremendous, although often underappreciated,
contributions he made to the disciplines of clinical pharmacology and
pharmacometrics. His humble brilliance will be missed and fondly remembered.”
Steve Riley
This e-mail message, together with any attachments, contains information of
Merck & Co., Inc. (126 East Lincoln Ave., P.O. Box 2000, Rahway, NJ USA 07065)
and/or its affiliates, that may be confidential, proprietary copyrighted and/or
legally privileged. (Direct contact information for affiliates is available
at - Contact us - https://www.msd.com/contact-us/.) It is intended solely
for the use of the individual or entity named on this message. If you are not
the intended recipient, and have received this message in error, please notify
us immediately by reply e-mail and then delete it from your system.
Thanks to nmusers for informing me of this sad news. I have known Tom for many
years but we only occasionally met face to face. I echo the sentiments of
others below who spoke of his depth of knowledge and gentleness. He helped me
many times when I was struggling with NONMEM and I think we always found a
solution. We wrote one publication together, a book chapter on the “Time Course
of Drug Effect”. This echoed what is my earliest citation of Tom’s scientific
contributions nearly 40 years age (Svec JM, Coleman RW, Mungall DR, Ludden TM.
Bayesian pharmacokinetic/pharmacodynamic forecasting of prothrombin response to
warfarin therapy: preliminary evaluation. Ther Drug Monit. 1985;7(2):174-80.).
Tom, I hope in your afterlife you will still be able to follow nmusers. Thank
you for all you have given to so many of us.
--
Nick Holford, Professor Emeritus Clinical Pharmacology, MBChB, FRACP
mobile: NZ+64(21) 46 23 53 ; FR+33(6) 62 32 46 72
email: [email protected]<mailto:[email protected]>
web: http://holford.fmhs.auckland.ac.nz/
Quoted reply history
From: [email protected] <[email protected]> On Behalf Of
Patel, Bela
Sent: Saturday, August 3, 2024 1:43 AM
To: ENE ETTE <[email protected]>; Diane Mould <[email protected]>;
Riley, Steve <[email protected]>; [email protected]
Subject: RE: [External email][NMusers] Sad news about Dr. Ludden
Some people who received this message don't often get email from
[email protected]<mailto:[email protected]>. Learn why this is
https://aka.ms/LearnAboutSenderIdentification
Public
Dear All,
I am extremely saddened to hear this news. As mentioned by Ene, Dr. Tom Ludden
was one of the pioneers in advancing pharmacometrics along with Dr. Beal and
Dr. Sheiner promoting its value and impact in drug discovery and development as
well as acceptance by the FDA. He provided invaluable scientific advice and
trained numerous scientists in pharmacometrics. He was a real gentle soul and
it was truly a privilege to have known him and be tutored by him.
May his soul rest in peace.
Sincerely,
Bela
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> On Behalf
Of ENE ETTE
Sent: Friday, August 2, 2024 5:30 PM
To: Diane Mould <[email protected]<mailto:[email protected]>>; Riley,
Steve <[email protected]<mailto:[email protected]>>;
[email protected]<mailto:[email protected]>
Subject: RE: [External email][NMusers] Sad news about Dr. Ludden
Some people who received this message don't often get email from
[email protected]<mailto:[email protected]>. Learn why this is
https://aka.ms/LearnAboutSenderIdentification
EXTERNAL EMAIL– Use caution with any links or file attachments.
Dear All:
In Dr. Ludden we lost an excellent scientist who helped to revolutionize and
advance clinical pharmacokinetics, pharmacometrics, clinical pharmacology, and
drug development. I’m indebted to him for the impact he made on my life as a
pharmacometrician, clinical pharmacologist, and drug developer while working
with him at the FDA. He started the Pharmacometrics Staff Unit which became
Pharmacometrics Division in later years.
May his soul rest in peace.
Sincerely,
Ene.
Sent from https://go.microsoft.com/fwlink/?LinkId=550986 for Windows
From: Diane Mould<mailto:[email protected]>
Sent: Friday, August 2, 2024 4:03 PM
To: Riley, Steve<mailto:[email protected]>;
[email protected]<mailto:[email protected]>
Subject: RE: [External email][NMusers] Sad news about Dr. Ludden
Dear All
I am very saddened to hear this news. Tom Ludden was one of the nicest and
smartest people that I have ever known. He was a gentle giant in our field and
I will miss him.
Best
Diane
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> On Behalf
Of Riley, Steve
Sent: Friday, August 2, 2024 2:41 PM
To: [email protected]<mailto:[email protected]>
Subject: [External email][NMusers] Sad news about Dr. Ludden
CAUTION: This email originated from outside the organization. Do not click
links or open attachments unless you recognize the sender and know the content
is safe.
Dear NM-Users,
Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday
evening, 30JUL2024.
I was able to get there over the weekend prior to visit him and his family.
During his wakeful moments we had some good scientific discussions.
We talked a lot about NONMEM and how its functionality and utility has expanded
since he retired. He was pleased to hear about the changes.
He was surrounded by family for the days leading up to the end. They were all
appreciative that I was able to get there and tell him (and them) how much he
meant to all of us and the impact he had on our careers.
I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay,
“I am forever grateful for the positive impact that Tom had on my life and
career, not to mention the tremendous, although often underappreciated,
contributions he made to the disciplines of clinical pharmacology and
pharmacometrics. His humble brilliance will be missed and fondly remembered.”
Steve Riley
This e-mail message, together with any attachments, contains information of
Merck & Co., Inc. (126 East Lincoln Ave., P.O. Box 2000, Rahway, NJ USA 07065)
and/or its affiliates, that may be confidential, proprietary copyrighted and/or
legally privileged. (Direct contact information for affiliates is available
at - Contact us - https://www.msd.com/contact-us/.) It is intended solely
for the use of the individual or entity named on this message. If you are not
the intended recipient, and have received this message in error, please notify
us immediately by reply e-mail and then delete it from your system.
We're very fortunate in this field to have an abundance or leaders who seem
entirely motivated by advancing the field and helping others with their
professional development. In my limited experience, more so than any other
field of bio medial research. Few however were as patient and generous as Tom.
Many in this group are probably aware of the story of how he came to have
NONMEM license #1 and how he was one of the few who gained Stuart's trust and
respect early in the history of PMX, and the critical role he played in bring
these methods into mainstream pharmaceutical research, a testament to both his
technical knowledge and leadership skills. Like many others I personally
benefited from my interactions with him.
Mark
Mark Sale M.D.
Vice President
Integrated Drug Development
[email protected]
Remote-Forestville CA
Office Hours 9 AM - 5 PM Eastern Time
+1 302-516-1684
www.certara.com
[Certara Logo]
Quoted reply history
From: [email protected] <[email protected]> On Behalf Of
Nick Holford
Sent: Saturday, August 3, 2024 1:20 AM
To: [email protected]
Subject: RE: [NMusers] Sad news about Dr. Ludden
CAUTION: This email originated from outside of Certara. Do not click links or
open attachments unless you recognize the sender and know the content is safe.
Thanks to nmusers for informing me of this sad news. I have known Tom for many
years but we only occasionally met face to face. I echo the sentiments of
others below who spoke of his depth of knowledge and gentleness. He helped me
many times when I was struggling with NONMEM and I think we always found a
solution. We wrote one publication together, a book chapter on the "Time Course
of Drug Effect". This echoed what is my earliest citation of Tom's scientific
contributions nearly 40 years age (Svec JM, Coleman RW, Mungall DR, Ludden TM.
Bayesian pharmacokinetic/pharmacodynamic forecasting of prothrombin response to
warfarin therapy: preliminary evaluation. Ther Drug Monit. 1985;7(2):174-80.).
Tom, I hope in your afterlife you will still be able to follow nmusers. Thank
you for all you have given to so many of us.
--
Nick Holford, Professor Emeritus Clinical Pharmacology, MBChB, FRACP
mobile: NZ+64(21) 46 23 53 ; FR+33(6) 62 32 46 72
email: [email protected]<mailto:[email protected]>
web: http://holford.fmhs.auckland.ac.nz/
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> On Behalf
Of Patel, Bela
Sent: Saturday, August 3, 2024 1:43 AM
To: ENE ETTE <[email protected]<mailto:[email protected]>>; Diane
Mould <[email protected]<mailto:[email protected]>>; Riley, Steve
<[email protected]<mailto:[email protected]>>;
[email protected]<mailto:[email protected]>
Subject: RE: [External email][NMusers] Sad news about Dr. Ludden
Some people who received this message don't often get email from
[email protected]<mailto:[email protected]>. Learn why this is
https://aka.ms/LearnAboutSenderIdentification
Public
Dear All,
I am extremely saddened to hear this news. As mentioned by Ene, Dr. Tom Ludden
was one of the pioneers in advancing pharmacometrics along with Dr. Beal and
Dr. Sheiner promoting its value and impact in drug discovery and development as
well as acceptance by the FDA. He provided invaluable scientific advice and
trained numerous scientists in pharmacometrics. He was a real gentle soul and
it was truly a privilege to have known him and be tutored by him.
May his soul rest in peace.
Sincerely,
Bela
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> On Behalf
Of ENE ETTE
Sent: Friday, August 2, 2024 5:30 PM
To: Diane Mould <[email protected]<mailto:[email protected]>>; Riley,
Steve <[email protected]<mailto:[email protected]>>;
[email protected]<mailto:[email protected]>
Subject: RE: [External email][NMusers] Sad news about Dr. Ludden
Some people who received this message don't often get email from
[email protected]<mailto:[email protected]>. Learn why this is
https://aka.ms/LearnAboutSenderIdentification
EXTERNAL EMAIL- Use caution with any links or file attachments.
Dear All:
In Dr. Ludden we lost an excellent scientist who helped to revolutionize and
advance clinical pharmacokinetics, pharmacometrics, clinical pharmacology, and
drug development. I'm indebted to him for the impact he made on my life as a
pharmacometrician, clinical pharmacologist, and drug developer while working
with him at the FDA. He started the Pharmacometrics Staff Unit which became
Pharmacometrics Division in later years.
May his soul rest in peace.
Sincerely,
Ene.
Sent from https://go.microsoft.com/fwlink/?LinkId=550986 for Windows
From: Diane Mould<mailto:[email protected]>
Sent: Friday, August 2, 2024 4:03 PM
To: Riley, Steve<mailto:[email protected]>;
[email protected]<mailto:[email protected]>
Subject: RE: [External email][NMusers] Sad news about Dr. Ludden
Dear All
I am very saddened to hear this news. Tom Ludden was one of the nicest and
smartest people that I have ever known. He was a gentle giant in our field and
I will miss him.
Best
Diane
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> On Behalf
Of Riley, Steve
Sent: Friday, August 2, 2024 2:41 PM
To: [email protected]<mailto:[email protected]>
Subject: [External email][NMusers] Sad news about Dr. Ludden
CAUTION: This email originated from outside the organization. Do not click
links or open attachments unless you recognize the sender and know the content
is safe.
Dear NM-Users,
Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday
evening, 30JUL2024.
I was able to get there over the weekend prior to visit him and his family.
During his wakeful moments we had some good scientific discussions.
We talked a lot about NONMEM and how its functionality and utility has expanded
since he retired. He was pleased to hear about the changes.
He was surrounded by family for the days leading up to the end. They were all
appreciative that I was able to get there and tell him (and them) how much he
meant to all of us and the impact he had on our careers.
I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay,
"I am forever grateful for the positive impact that Tom had on my life and
career, not to mention the tremendous, although often underappreciated,
contributions he made to the disciplines of clinical pharmacology and
pharmacometrics. His humble brilliance will be missed and fondly remembered."
Steve Riley
This e-mail message, together with any attachments, contains information of
Merck & Co., Inc. (126 East Lincoln Ave., P.O. Box 2000, Rahway, NJ USA 07065)
and/or its affiliates, that may be confidential, proprietary copyrighted and/or
legally privileged. (Direct contact information for affiliates is available
at - Contact us - https://www.msd.com/contact-us/.) It is intended solely
for the use of the individual or entity named on this message. If you are not
the intended recipient, and have received this message in error, please notify
us immediately by reply e-mail and then delete it from your system.
This message (including any attachments) may contain confidential, proprietary,
privileged and/or private information. The information is intended to be for
the use of the individual or entity designated above. If you are not the
intended recipient of this message, please notify the sender immediately, and
delete the message and any attachments. Any disclosure, reproduction,
distribution or other use of this message or any attachments by an individual
or entity other than the intended recipient is prohibited.
It is sad to learn about Dr Tom Ludden’s demise. I would like to share my
INTERACTION with him.
$THETA Our initial meeting happened when I was at Georgetown University,
Washington DC and he was with ICON (or its precursor). If I remember correctly,
Dr Carl Peck encouraged Dr Ludden to join the FDA. The first estimate of his
impact was realized when I joined FDA, by which time he already left FDA. Dr
Ludden was able to attract some of the top scientists to join FDA, which was a
challenge in those days. He continued his professorial spirit by teaching
pharmacometrics to aspiring clinical pharmacologists. Gradually, our meetings
converged on topics related to strategic direction of the field. He was kind
enough to meet with me to inspire me and offer sound advice. He was always at
the global minimum, was a true ‘gentleman’ through our iterations. Dr Ludden
laid one of the initial foundations of Pharmacometrics at FDA. His
contributions to the NONMEM community are well known. I cannot $ESTIMATE his
impact on our field both through transforming FDA reviews and making NONMEM
more useful for scientists. There is no uncertainty that the shoes he walked in
cannot be filled by anybody (;$COVARIANCE).
In conclusion, he left a strong $PRIOR; and $SIMULATION predicts that his
impact will continue to last forever! I will always remember him.
Joga
Quoted reply history
From: [email protected] <[email protected]> on behalf of
Riley, Steve <[email protected]>
Date: Friday, August 2, 2024 at 2:53 PM
To: [email protected] <[email protected]>
Subject: [NMusers] Sad news about Dr. Ludden
You don't often get email from [email protected]. Learn why this is
https://aka.ms/LearnAboutSenderIdentification
CAUTION: This message originated from a non-UMB email system. Hover over any
links before clicking and use caution opening attachments.
Dear NM-Users,
Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday
evening, 30JUL2024.
I was able to get there over the weekend prior to visit him and his family.
During his wakeful moments we had some good scientific discussions.
We talked a lot about NONMEM and how its functionality and utility has expanded
since he retired. He was pleased to hear about the changes.
He was surrounded by family for the days leading up to the end. They were all
appreciative that I was able to get there and tell him (and them) how much he
meant to all of us and the impact he had on our careers.
I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay,
“I am forever grateful for the positive impact that Tom had on my life and
career, not to mention the tremendous, although often underappreciated,
contributions he made to the disciplines of clinical pharmacology and
pharmacometrics. His humble brilliance will be missed and fondly remembered.”
Steve Riley
What a giant. I always appreciated his kindness in responding to my naiive
questions about coding NONMEM.
Paul R. Hutson, PharmD, BCOP
Professor (CHS)
UW School of Pharmacy
Director, UW Madison Transdisciplinary Center for Research in Psychoactive
https://www.research.pharmacy.wisc.edu/tcrps
Faculty Leader, Paul P. Carbone Comprehensive Cancer Center Cancer Pharmacology
https://cancer.wisc.edu/research/resources/ddc/cancer-pharmacology/
T: 608.263.2496
[email protected]
Quoted reply history
From: [email protected] <[email protected]> On Behalf Of
Ekaterina Gibiansky
Sent: Friday, August 2, 2024 3:19 PM
To: Diane Mould <[email protected]>; Riley, Steve <[email protected]>;
[email protected]
Subject: Re: [External email][NMusers] Sad news about Dr. Ludden
I second everything Steve, and Mark, and Diane said. All of us who were blessed
to work alongside him will forever remember him with fondness and gratitude.
And let's not forget that he was the only one who Stuart Beal trusted to take
care of NONMEM and bring it forward into 21st century.
Katya
On 8/2/2024 3:55 PM, Diane Mould wrote:
Dear All
I am very saddened to hear this news. Tom Ludden was one of the nicest and
smartest people that I have ever known. He was a gentle giant in our field and
I will miss him.
Best
Diane
From: [email protected]<mailto:[email protected]>
<[email protected]><mailto:[email protected]> On Behalf
Of Riley, Steve
Sent: Friday, August 2, 2024 2:41 PM
To: [email protected]<mailto:[email protected]>
Subject: [External email][NMusers] Sad news about Dr. Ludden
CAUTION: This email originated from outside the organization. Do not click
links or open attachments unless you recognize the sender and know the content
is safe.
Dear NM-Users,
Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday
evening, 30JUL2024.
I was able to get there over the weekend prior to visit him and his family.
During his wakeful moments we had some good scientific discussions.
We talked a lot about NONMEM and how its functionality and utility has expanded
since he retired. He was pleased to hear about the changes.
He was surrounded by family for the days leading up to the end. They were all
appreciative that I was able to get there and tell him (and them) how much he
meant to all of us and the impact he had on our careers.
I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay,
“I am forever grateful for the positive impact that Tom had on my life and
career, not to mention the tremendous, although often underappreciated,
contributions he made to the disciplines of clinical pharmacology and
pharmacometrics. His humble brilliance will be missed and fondly remembered.”
Steve Riley
Dear nmusers,
It is so sad that Tom Ludden is gone. I remember well his many contributions
to NONMEM.
He was one of Stuart's original fellows and thus one of the original users of
NONMEM.
He was the voice of calm during the panicky days after Stuart Beal's
unexpected death.
Tom pitched in to help me finalize NONMEM 6 - a task I could never have done on
my own.
He was always calm and thoughtful and friendly and smart.
And then he was able to recruit Bob Bauer (Tom recognized the need for an exit
strategy!)
The many tributes to him in this nmusers thread are inspiring.
-- Alison Boeckmann
Quoted reply history
On Fri, Aug 2, 2024, at 3:51 PM, Bauer, Robert wrote:
> Dear Nmusers:
> The PK/PD scientists here at ICON express our sincere condolences on the
> passing of Tom Ludden. As mentioned by several already, Tom was very
> instrumental in transitioning the NONMEM software development from the labs
> of Beal, Sheiner, and Boeckmann at UCSF, to Globomax, then to ICON. The
> development team at ICON was greatly aided in adding additional features from
> NONMEM VI to NONMEM 7 with his expert direction and his connections with many
> in the PK/PD modeling and population analysis community offering their inputs
> regarding desired features (and fixing a few bugs!). Tom continued with
> ICON all the way through the development of NONMEM 7.2 before his retirement
> in Spring 2011, and oversaw the incorporation of dynamic memory allocation,
> as well as parallel computing that were first incorporated in that version,
> which was a significant milestone in the performance of NONMEM. In a
> retirement speech some years ago Tom expressed that his greatest desire was
> that he was useful to the PK/PD and pharmacometrics field. He certainly
> accomplished this in a way few of us can ever hope to achieve.
>
>
> Robert J. Bauer, Ph.D.
> Senior Director
> Pharmacometrics R&D
> ICON Early Phase
> 731 Arbor way, suite 100
> Blue Bell, PA 19422
> Office: (215) 616-6428
> Mobile: (925) 286-0769
> [email protected]
> www.iconplc.com
>
>
>
>
I agree. While I only met Tom in person a few times we interacted quite a bit
in my early days of PMx and NONMEM. Tom was immensely clever, kind,
unassuming, understanding and supportive. A pleasure to chat with and to learn
from.
Steve
Stephen Duffull
Senior Scientific Advisor, Certara Drug Development Solutions
[email protected]<mailto:[email protected]>
Dunedin, Aotearoa New Zealand (NZ Time Zone: UTC +12)
http://www.certara.com/
[cid:[email protected]]
Quoted reply history
From: [email protected] <[email protected]> On Behalf Of
Paul Hutson
Sent: Sunday, August 4, 2024 3:32 AM
To: Ekaterina Gibiansky <[email protected]>; Diane Mould
<[email protected]>; Riley, Steve <[email protected]>;
[email protected]
Subject: RE: [External email][NMusers] Sad news about Dr. Ludden
Some people who received this message don't often get email from
[email protected]<mailto:[email protected]>. Learn why this is
https://aka.ms/LearnAboutSenderIdentification
CAUTION: This email originated from outside of Certara. Do not click links or
open attachments unless you recognize the sender and know the content is safe.
What a giant. I always appreciated his kindness in responding to my naiive
questions about coding NONMEM.
Paul R. Hutson, PharmD, BCOP
Professor (CHS)
UW School of Pharmacy
Director, UW Madison Transdisciplinary Center for Research in Psychoactive
https://www.research.pharmacy.wisc.edu/tcrps
Faculty Leader, Paul P. Carbone Comprehensive Cancer Center Cancer Pharmacology
https://cancer.wisc.edu/research/resources/ddc/cancer-pharmacology/
T: 608.263.2496
[email protected]<mailto:[email protected]>
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> On Behalf
Of Ekaterina Gibiansky
Sent: Friday, August 2, 2024 3:19 PM
To: Diane Mould <[email protected]<mailto:[email protected]>>; Riley,
Steve <[email protected]<mailto:[email protected]>>;
[email protected]<mailto:[email protected]>
Subject: Re: [External email][NMusers] Sad news about Dr. Ludden
I second everything Steve, and Mark, and Diane said. All of us who were blessed
to work alongside him will forever remember him with fondness and gratitude.
And let's not forget that he was the only one who Stuart Beal trusted to take
care of NONMEM and bring it forward into 21st century.
Katya
On 8/2/2024 3:55 PM, Diane Mould wrote:
Dear All
I am very saddened to hear this news. Tom Ludden was one of the nicest and
smartest people that I have ever known. He was a gentle giant in our field and
I will miss him.
Best
Diane
From: [email protected]<mailto:[email protected]>
<[email protected]><mailto:[email protected]> On Behalf
Of Riley, Steve
Sent: Friday, August 2, 2024 2:41 PM
To: [email protected]<mailto:[email protected]>
Subject: [External email][NMusers] Sad news about Dr. Ludden
CAUTION: This email originated from outside the organization. Do not click
links or open attachments unless you recognize the sender and know the content
is safe.
Dear NM-Users,
Regrettably, I am writing to let you know that Dr. Ludden passed away Tuesday
evening, 30JUL2024.
I was able to get there over the weekend prior to visit him and his family.
During his wakeful moments we had some good scientific discussions.
We talked a lot about NONMEM and how its functionality and utility has expanded
since he retired. He was pleased to hear about the changes.
He was surrounded by family for the days leading up to the end. They were all
appreciative that I was able to get there and tell him (and them) how much he
meant to all of us and the impact he had on our careers.
I think memories of Dr. Ludden were characterized perfectly by Marc Gastonguay,
"I am forever grateful for the positive impact that Tom had on my life and
career, not to mention the tremendous, although often underappreciated,
contributions he made to the disciplines of clinical pharmacology and
pharmacometrics. His humble brilliance will be missed and fondly remembered."
Steve Riley
This message (including any attachments) may contain confidential, proprietary,
privileged and/or private information. The information is intended to be for
the use of the individual or entity designated above. If you are not the
intended recipient of this message, please notify the sender immediately, and
delete the message and any attachments. Any disclosure, reproduction,
distribution or other use of this message or any attachments by an individual
or entity other than the intended recipient is prohibited.
Dear all,
This is indeed very sad. I concur with everyone. Ton was a very nice
person, always open to listen to you and provide advice and support. II met
with him a couple of times in the early 90ies and particularly in one
formal meeting (probably in 1992) when he was heading Pharmacometry at FDA.
He has been so supportive to my popPK/PD plans to support the filing of
docetaxel (Taxotere) that when I got back in my company (Rhone Poulenc, now
Sanofi) that the SVP of Regulatory asked me "what it is that you are doing?
population PK???? Given such positive feedback from Tom (and FDA) I got
full support to get the data and analysis done on time for the filing.
Tom's support changed my life as well as the one of patients
receiving Taxotere with the Boxed Warning about elevated hepatic enzymes
(still in the US PI) and the dose adjustment in the EU SCP.
I will be indebted to him forever.
René
https://www.avast.com/sig-email?utm_medium=email&utm_source=link&utm_campaign=sig-email&utm_content=webmail
Sans
virus.www.avast.com
https://www.avast.com/sig-email?utm_medium=email&utm_source=link&utm_campaign=sig-email&utm_content=webmail
<#DAB4FAD8-2DD7-40BB-A1B8-4E2AA1F9FDF2>
Quoted reply history
Le ven. 2 août 2024 à 20:56, Riley, Steve <[email protected]> a écrit :
> Dear NM-Users,
>
>
>
> Regrettably, I am writing to let you know that Dr. Ludden passed away
> Tuesday evening, 30JUL2024.
>
> I was able to get there over the weekend prior to visit him and his
> family.
>
> During his wakeful moments we had some good scientific discussions.
>
> We talked a lot about NONMEM and how its functionality and utility has
> expanded since he retired. He was pleased to hear about the changes.
>
> He was surrounded by family for the days leading up to the end. They were
> all appreciative that I was able to get there and tell him (and them) how
> much he meant to all of us and the impact he had on our careers.
>
>
>
> I think memories of Dr. Ludden were characterized perfectly by Marc
> Gastonguay, “I am forever grateful for the positive impact that Tom had on
> my life and career, not to mention the tremendous, although often
> underappreciated, contributions he made to the disciplines of clinical
> pharmacology and pharmacometrics. His humble brilliance will be missed and
> fondly remembered.”
>
>
> Steve Riley
>
>
>
Dear All,
I am deeply saddened to hear this news. During my PhD in Minnesota, I had
the privilege of engaging with Dr. Ludden through Skype interactions. In
the advanced PK course taught by Dr. Bill Elmquist, we had a unique
assignment to write an essay on the scientific impact and life journey of a
notable scientist in the field of Pharmacometrics. I don't recall how I
chose Dr. Ludden, but he was incredibly welcoming and generously shared
numerous stories about his personal and professional experiences. I cherish
those conversations and the insights he provided. I hope to find this essay
in one of my emails, and if I do, I will share it with you
Rest in peace, Dr. Ludden.
Warm regards,
Vijay
Quoted reply history
On Mon, Aug 5, 2024 at 4:49 PM Rene Bruno <[email protected]> wrote:
> Dear all,
>
> This is indeed very sad. I concur with everyone. Ton was a very nice
> person, always open to listen to you and provide advice and support. II met
> with him a couple of times in the early 90ies and particularly in one
> formal meeting (probably in 1992) when he was heading Pharmacometry at FDA.
> He has been so supportive to my popPK/PD plans to support the filing of
> docetaxel (Taxotere) that when I got back in my company (Rhone Poulenc, now
> Sanofi) that the SVP of Regulatory asked me "what it is that you are doing?
> population PK???? Given such positive feedback from Tom (and FDA) I got
> full support to get the data and analysis done on time for the filing.
> Tom's support changed my life as well as the one of patients
> receiving Taxotere with the Boxed Warning about elevated hepatic enzymes
> (still in the US PI) and the dose adjustment in the EU SCP.
>
> I will be indebted to him forever.
>
> René
>
>
> https://www.avast.com/sig-email?utm_medium=email&utm_source=link&utm_campaign=sig-email&utm_content=webmail
> Sans
> virus.www.avast.com
> https://www.avast.com/sig-email?utm_medium=email&utm_source=link&utm_campaign=sig-email&utm_content=webmail
> <#m_-7736047338385682954_DAB4FAD8-2DD7-40BB-A1B8-4E2AA1F9FDF2>
>
> Le ven. 2 août 2024 à 20:56, Riley, Steve <[email protected]> a
> écrit :
>
>> Dear NM-Users,
>>
>>
>>
>> Regrettably, I am writing to let you know that Dr. Ludden passed away
>> Tuesday evening, 30JUL2024.
>>
>> I was able to get there over the weekend prior to visit him and his
>> family.
>>
>> During his wakeful moments we had some good scientific discussions.
>>
>> We talked a lot about NONMEM and how its functionality and utility has
>> expanded since he retired. He was pleased to hear about the changes.
>>
>> He was surrounded by family for the days leading up to the end. They were
>> all appreciative that I was able to get there and tell him (and them) how
>> much he meant to all of us and the impact he had on our careers.
>>
>>
>>
>> I think memories of Dr. Ludden were characterized perfectly by Marc
>> Gastonguay, “I am forever grateful for the positive impact that Tom had on
>> my life and career, not to mention the tremendous, although often
>> underappreciated, contributions he made to the disciplines of clinical
>> pharmacology and pharmacometrics. His humble brilliance will be missed and
>> fondly remembered.”
>>
>>
>> Steve Riley
>>
>>
>>
>
--
~Vijay