Dear users:
Some of you who attended the PAGE meeting in Venice last week asked me about
the quasi-random parametric expectation maximization method (QRPEM) that was
being presented by Bob Leary. This quasi-random sampling method used in QRPEM
is the Sobol method, and is available in NONMEM 7.2 for importance sampling or
direct sampling. Please read section 1.21., RANMETHOD option (around page 34),
in ..\guides\nm720.pdf of your nonmem installation for implementing this
sampling method for importance sampling.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics, R&D
ICON Development Solutions
7740 Milestone Parkway
Suite 150
Hanover, MD 21076
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: http://www.iconplc.com/