Dear NMUsers,
Is anyone aware of any published population PK analysis of simvastatin?
Either PubMed or google search has resulted in none (I might miss something
out though). In addition, it seems that all statins share this lack of
published population PK information. Any ideas or comments?
Thank you,
Howard
Howard Lee, MD, PhD
Associate Adjunct Professor
Director, Center for Drug Development Science
Department of Biopharmaceutical Sciences
School of Pharmacy
University of California, San Francisco
UC Washington Center
1608 Rhode Island Avenue, NW
Washington , DC 20036
Tel: (202)785-5449
Fax: (202)822-5040
Cell: (240)994-8384
Web: http://cdds.ucsf.edu http://cdds.ucsf.edu/
Email: <mailto:[EMAIL PROTECTED]> [EMAIL PROTECTED] ;
<mailto:[EMAIL PROTECTED]> [EMAIL PROTECTED]
Population PK Analysis of Simvastatin
I am not sure if this reference is helpful
Faltaos DW, Urien S, Carreau V, Chauvenet M, Hulot JS, Giral P, Bruckert E,
Lechat P. Use of an indirect effect model to describe the LDL
cholesterol-lowering effect by statins in hypercholesterolaemic patients.
Fundam Clin Pharmacol. 2006 Jun;20(3):321-30.
Ganesh
---------------------------------------
Ganesh M Mugundu
Graduate Student
College of Pharmacy
University of Cincinnati
Cell: 513 417 4847
BLOG: http://pk-pd.blogspot.com/
WebPage: www.geocities.com/ganaish
If you want to get somewhere, you have to know where you want to go and how to
get there. Then NEVER, NEVER, NEVER GIVE UP."
Norman Vincent Peale
Dear Howard,
In addition to the paper which Ganesh sent you,
this paper will probably be helpful:
Hatanaka T, Honda S, Sasaki S, Katayama K, Koizumi T.
Pharmacokinetic and pharmacodynamic evaluation for tissue-selective inhibition
of cholesterol synthesis by pravastatin.
J Pharmacokinet Biopharm. 1998 Jun;26(3):329-47.
Best regards
Juergen
-----Ursprüngliche Nachricht-----
Von: "Howard Lee" <[EMAIL PROTECTED]>
Gesendet: 23.04.08 03:58:16
An: "'Ganesh Mugundu'" <[EMAIL PROTECTED]>
CC: <[email protected]>
Betreff: RE: [NMusers] Population PK Analysis of Simvastatin
Dear Ganesh,
Thank you for your reply and inforamtion. In the said paper, however, the
simvastatin PK was not modeled. Instead, dose-PD relationship was explored.
Thank you again anyway.
More inputs from others are welcome.
Howard
Quoted reply history
-----Original Message-----
From: Ganesh Mugundu [mailto:[EMAIL PROTECTED]
Sent: Tuesday, April 22, 2008 9:47 PM
To: Howard Lee; [email protected]
Subject: Re: [NMusers] Population PK Analysis of Simvastatin
I am not sure if this reference is helpful
Faltaos DW, Urien S, Carreau V, Chauvenet M, Hulot JS, Giral P, Bruckert E,
Lechat P. Use of an indirect effect model to describe the LDL
cholesterol-lowering effect by statins in hypercholesterolaemic patients.
Fundam Clin Pharmacol. 2006 Jun;20(3):321-30.
Ganesh
---------------------------------------
Ganesh M Mugundu
Graduate Student
College of Pharmacy
University of Cincinnati
Cell: 513 417 4847
BLOG: http://pk-pd.blogspot.com/
WebPage: www.geocities.com/ganaish
If you want to get somewhere, you have to know where you want to go and how
to get there. Then NEVER, NEVER, NEVER GIVE UP."
Norman Vincent Peale
Hi Howard,
Here are a few references that I am aware of.
I hope these help.
*P.S.* The first is a very good review with original refrences cited.
*1-* Williams D, Feely J. Pharmacokinetic-pharmacodynamic drug interactions
with HMG-CoA reductase inhibitors. Clin Pharmacokinet. 2002;41(5):343-70.
*2-* Duggan D, Vickers S. Physiological disposition of HMG-CoAreductase
inhibitors. Drug Metab Rev 1990; 22: 333-62.
*3-* Todd P, Goa K. Simvastatin : a review of its pharmacological properties
and potential in hypercholesterolaemia. Drugs 1990; 40: 583-607.
*4- *Vickers S, Duncan C, Chen I, et al. Metabolic disposition studies on
simvastatin, a cholesterol-lowering prodrug. Drug Metab Dispos 1990; 18:
138-45.
**
*Murad Melhem, PhD*
*Cognigen Corporation*
*Buffalo, NY
*
Quoted reply history
On Tue, Apr 22, 2008 at 9:19 PM, Howard Lee <[EMAIL PROTECTED]> wrote:
> Dear NMUsers,
>
>
>
> Is anyone aware of any published population PK analysis of simvastatin?
> Either PubMed or google search has resulted in none (I might miss something
> out though). In addition, it seems that all statins share this lack of
> published population PK information. Any ideas or comments?
>
>
>
> Thank you,
>
>
>
> Howard
>
>
>
>
>
>
>
> *Howard Lee, MD, PhD*
>
>
>
> Associate Adjunct Professor
>
> Director, Center for Drug Development Science
>
> Department of Biopharmaceutical Sciences
>
> School of Pharmacy
>
> University of California, San Francisco
>
>
>
> UC Washington Center
>
> 1608 Rhode Island Avenue, NW
>
> Washington , DC 20036
>
> Tel: (202)785-5449
>
> Fax: (202)822-5040
>
> Cell: (240)994-8384
>
> Web: http://cdds.ucsf.edu
>
> Email: [EMAIL PROTECTED] ; [EMAIL PROTECTED]
>
>
>
>
>