RE: Population PK Analysis of Simvastatin
Dear Howard,
In addition to the paper which Ganesh sent you,
this paper will probably be helpful:
Hatanaka T, Honda S, Sasaki S, Katayama K, Koizumi T.
Pharmacokinetic and pharmacodynamic evaluation for tissue-selective inhibition
of cholesterol synthesis by pravastatin.
J Pharmacokinet Biopharm. 1998 Jun;26(3):329-47.
Best regards
Juergen
-----Ursprüngliche Nachricht-----
Von: "Howard Lee" <[EMAIL PROTECTED]>
Gesendet: 23.04.08 03:58:16
An: "'Ganesh Mugundu'" <[EMAIL PROTECTED]>
CC: <[email protected]>
Betreff: RE: [NMusers] Population PK Analysis of Simvastatin
Dear Ganesh,
Thank you for your reply and inforamtion. In the said paper, however, the
simvastatin PK was not modeled. Instead, dose-PD relationship was explored.
Thank you again anyway.
More inputs from others are welcome.
Howard
Quoted reply history
-----Original Message-----
From: Ganesh Mugundu [mailto:[EMAIL PROTECTED]
Sent: Tuesday, April 22, 2008 9:47 PM
To: Howard Lee; [email protected]
Subject: Re: [NMusers] Population PK Analysis of Simvastatin
I am not sure if this reference is helpful
Faltaos DW, Urien S, Carreau V, Chauvenet M, Hulot JS, Giral P, Bruckert E,
Lechat P. Use of an indirect effect model to describe the LDL
cholesterol-lowering effect by statins in hypercholesterolaemic patients.
Fundam Clin Pharmacol. 2006 Jun;20(3):321-30.
Ganesh
---------------------------------------
Ganesh M Mugundu
Graduate Student
College of Pharmacy
University of Cincinnati
Cell: 513 417 4847
BLOG: http://pk-pd.blogspot.com/
WebPage: www.geocities.com/ganaish
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