Re: Population PK Analysis of Simvastatin
Hi Howard,
Here are a few references that I am aware of.
I hope these help.
*P.S.* The first is a very good review with original refrences cited.
*1-* Williams D, Feely J. Pharmacokinetic-pharmacodynamic drug interactions
with HMG-CoA reductase inhibitors. Clin Pharmacokinet. 2002;41(5):343-70.
*2-* Duggan D, Vickers S. Physiological disposition of HMG-CoAreductase
inhibitors. Drug Metab Rev 1990; 22: 333-62.
*3-* Todd P, Goa K. Simvastatin : a review of its pharmacological properties
and potential in hypercholesterolaemia. Drugs 1990; 40: 583-607.
*4- *Vickers S, Duncan C, Chen I, et al. Metabolic disposition studies on
simvastatin, a cholesterol-lowering prodrug. Drug Metab Dispos 1990; 18:
138-45.
**
*Murad Melhem, PhD*
*Cognigen Corporation*
*Buffalo, NY
*
Quoted reply history
On Tue, Apr 22, 2008 at 9:19 PM, Howard Lee <[EMAIL PROTECTED]> wrote:
> Dear NMUsers,
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> Is anyone aware of any published population PK analysis of simvastatin?
> Either PubMed or google search has resulted in none (I might miss something
> out though). In addition, it seems that all statins share this lack of
> published population PK information. Any ideas or comments?
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> Thank you,
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> Howard
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> *Howard Lee, MD, PhD*
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> Associate Adjunct Professor
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> Director, Center for Drug Development Science
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> Department of Biopharmaceutical Sciences
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> School of Pharmacy
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> University of California, San Francisco
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> UC Washington Center
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> 1608 Rhode Island Avenue, NW
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> Washington , DC 20036
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> Tel: (202)785-5449
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> Fax: (202)822-5040
>
> Cell: (240)994-8384
>
> Web: http://cdds.ucsf.edu
>
> Email: [EMAIL PROTECTED] ; [EMAIL PROTECTED]
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