Dear NONMEM users,
I am working on a kinetic data set from automated peritoneal dialysis
patients, with concentration measurements in plasma and dialysate.
For the 24 h of this study, APD patients were placed on a standard dialysis
prescription of three 2.5%, 2-L exchanges over a period of 8 h during the
day using the cycler (automated session), followed by two 2.5%, 2-L dwells
of about 8 h each over the course of the evening and overnight (manual
session).
I think that Dialysis compartment have to be reset after exchanging
dialysate.
But it is difficult for me to prepare the data set.
Could you explain the data preparation skill for peritoneal dialysis ?
some data set is
#ID TIME EVID DWEL DV CMT AMT
1 9:33 4 0 0 1 795 <-- Drug
administration (IV bolus)
1 10:30 0 1 104.15 1 0 <-- Plasma concentration
on 1 dwell (APD)
1 11:00 0 1 103.54 1 0
1 11:15 0 1 2.82 2 0 <-- Dialysate
concentration on 1 dwell (APD)
1 12:20 0 1 11.92 2 0
1 12:30 0 1 84.77 1 0
1 13:10 0 2 78.3 1 0 <-- Plasma concentration
on 2 dwell (APD)
1 13:40 0 2 76.02 1 0
1 13:56 0 2 2.9 2 0 <-- Dialysate
concentration on 2 dwell (APD)
1 15:00 0 2 12.88 2 0
1 15:11 0 2 69.52 1 0
1 15:52 0 3 66.19 1 0 <-- Plasma concentration
on 3 dwell (APD)
1 16:20 0 3 65.11 1 0
1 16:39 0 3 4.25 2 0 <-- Dialysate
concentration on 3 dwell (APD)
1 17:45 0 3 11.99 2 0
1 17:50 0 3 62.36 1 0
1 22:00 0 4 48.91 1 0 <-- Plasma concentration
on 4 dwell (PD)
1 26:00 0 4 41.55 1 0
1 26:17 0 4 22.56 2 0 <-- Dialysate
concentration on 4 dwell (PD)
1 28:12 0 5 33 1 0 <-- Plasma concentration
on 5 dwell (PD)
1 34:00 0 5 26.99 1 0
1 34:30 0 5 13.79 2 0 <-- Dialysate
concentration on 5 dwell (PD)
Each Dwell's start and end time is
1st : start 10:10
1st : end 12:40
2nd : start 12:40
2nd : end 15:24
3rd : start 15:24
3rd : end 18:09
4th : start 18:11
4th : end 26:16
5th : start 26:26
5th : end 34:20
Thank you for the help.
Best wishes
Min-Gul Kim
---
Min-Gul Kim, MD, MS
Research Doctor of Dept of Clinical Pharmacology
Seoul National University Hospital,
28 Yeongeon-Dong Jongno-Gu, Seoul 110-744
Republic of Korea
Tel: 82-2-740-8290, Fax: 82-2-742-9252
Peritoneal Dialysis Data preparation
Min-Gul,
To reset the dialysis CMT you should set CMT=-2 (negative CMT means reset and
turn off this CMT) then set CMT=2 to turn the CMT on again at the time when
dialysis collection resumes. In both cases you should use EVID=2 to signal to
NONMEM to reset and set the dialysate CMT.
Note that the prediction in the dialysis CMT is the amount of drug excreted
into the dialysate collection during the collection interval. It is not a
concentration. If you want to predict the concentration then you will have to
supply the volume of the collection e.g. a data item called VOLD, then set the
scale factor S2=VOLD.
In the example below I have assumed that the first dialysate collection is
started at 10:00 and stops at 11:15. It is started again 1 h after the first
collection has finished at 12:15. The first 2 records at 9:33 make sure the
dialysis collection compartment is off until the first collection is started at
10:00.
Nick
> Min-Gul Kim wrote:
>
> I am working on a kinetic data set from automated peritoneal dialysis
> patients, with concentration measurements in plasma and dialysate.
[stuff deleted]
> I think that Dialysis compartment have to be reset after exchanging dialysate.
>
>
> #ID TIME EVID DWEL DV CMT AMT
> 1 9:33 2 1 0 2 0 Set Dialysis CMT
> 1 9:33 2 1 0 -2 0 Reset Dialysis CMT
> 1 9:33 4 0 0 1 795 IV bolus
> 1 10:00 2 1 0 2 0 Turn on Dialysis CMT
> 1 10:30 0 1 104.15 1 0 Plasma conc
> 1 11:00 0 1 103.54 1 0
> 1 11:15 0 1 2.82 2 0 Dialysate conc
> 1 11:15 2 1 0 -2 0 Reset Dialysis CMT
> 1 12:15 2 1 0 2 0 Turn on Dialysis CMT
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
www.health.auckland.ac.nz/pharmacology/staff/nholford