Dear nmusers:
You are invited to the following webinar:
ISoP MCS SIG Webinar Series
presents
Robert Bauer, Ph.D.
Pharmacometrics and PK/PD Modeling & Simulation, ICON Clinical Research, LLC.
Seminar Title
Understanding the Methodology and Uses of Some New Features in NONMEM 7.5:
Clinical Trial Design Evaluation and Optimization, and Delay Differential
Equations
July 14, 2021 @ 11 AM EST
Abstract
Two major features newly developed in NONMEM 7.5 are modelling delays, and
clinical trial design evaluation and optimization. Algorithms that model
delays for biological problems are explained, particularly cell lifespan and
cell maturation are discussed. These delays may be modelled either as a
discrete delay, or as a distributed delay, the most common being gamma
distributed and Weibull distributed. The numerical integrator tools and
techniques required to model each type of delay is discussed, describing their
behavior, and their pros and cons in terms of ease of use, efficiency,
stability, and stiffness. In addition, the tools and techniques of clinical
trial design and evaluation and optimization are discussed. The goal of
clinical trial design is to find times and doses that are most efficient and
economical to obtain the desired information about a therapeutic. In
particular, good quality parameters of the PK/PD model describing that
therapeutic in humans desired. For example, we may want to determine the
sample times which gives us the lowest possible standard errors to the
population parameters, or determine cohorts that a have the ideal combination
of dosing regimen and sample times. Often we wish to also take into account
the robustness of a design, that is, determine a sampling strategy that is rich
enough to account for the variations in PK/PD parameters that are likely to
occur in a set of subjects.
Registration
Register in advance for this webinar (open to nonmembers) here (Webinar
https://nam11.safelinks.protection.outlook.com/?url=http%3A%2F%2Finsp.memberclicks.net%2Fmessage2%2Flink%2F431312ce-6cb9-4438-af75-1039416b4f64%2F1&data=04%7C01%7Ccarl.panetta%40stjude.org%7Cf9208de0462c4b5f50b908d94604c4d5%7C22340fa892264871b677d3b3e377af72%7C0%7C0%7C637617808589355430%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=eIqf94bFbL%2Bhd%2FbOKPROk30D1R6TYX9JnIEtZOuJyuw%3D&reserved=0)
For additional details about the MCS SIG webinars visit:
https://nam11.safelinks.protection.outlook.com/?url=http%3A%2F%2Finsp.memberclicks.net%2Fmessage2%2Flink%2F431312ce-6cb9-4438-af75-1039416b4f64%2F2&data=04%7C01%7Ccarl.panetta%40stjude.org%7Cf9208de0462c4b5f50b908d94604c4d5%7C22340fa892264871b677d3b3e377af72%7C0%7C0%7C637617808589365386%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=uEiC5QN8zb6ygT2RWvb%2FmyBmzhxbnNnkn8Q%2B6ccJV34%3D&reserved=0
For information about the MCS SIG visit:
https://nam11.safelinks.protection.outlook.com/?url=http%3A%2F%2Finsp.memberclicks.net%2Fmessage2%2Flink%2F431312ce-6cb9-4438-af75-1039416b4f64%2F3&data=04%7C01%7Ccarl.panetta%40stjude.org%7Cf9208de0462c4b5f50b908d94604c4d5%7C22340fa892264871b677d3b3e377af72%7C0%7C0%7C637617808589375344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=Wu%2FeGXrUjZW1KG53MWjnzJzQPPWyzirdaCa8ldtWwBY%3D&reserved=0