ISOP Webinar, New Features in NONMEM 7.5

Dear nmusers: You are invited to the following webinar: ISoP MCS SIG Webinar Series presents Robert Bauer, Ph.D. Pharmacometrics and PK/PD Modeling & Simulation, ICON Clinical Research, LLC. Seminar Title Understanding the Methodology and Uses of Some New Features in NONMEM 7.5: Clinical Trial Design Evaluation and Optimization, and Delay Differential Equations July 14, 2021 @ 11 AM EST Abstract Two major features newly developed in NONMEM 7.5 are modelling delays, and clinical trial design evaluation and optimization. Algorithms that model delays for biological problems are explained, particularly cell lifespan and cell maturation are discussed. These delays may be modelled either as a discrete delay, or as a distributed delay, the most common being gamma distributed and Weibull distributed. The numerical integrator tools and techniques required to model each type of delay is discussed, describing their behavior, and their pros and cons in terms of ease of use, efficiency, stability, and stiffness. In addition, the tools and techniques of clinical trial design and evaluation and optimization are discussed. The goal of clinical trial design is to find times and doses that are most efficient and economical to obtain the desired information about a therapeutic. In particular, good quality parameters of the PK/PD model describing that therapeutic in humans desired. For example, we may want to determine the sample times which gives us the lowest possible standard errors to the population parameters, or determine cohorts that a have the ideal combination of dosing regimen and sample times. Often we wish to also take into account the robustness of a design, that is, determine a sampling strategy that is rich enough to account for the variations in PK/PD parameters that are likely to occur in a set of subjects. Registration Register in advance for this webinar (open to nonmembers) here (Webinar https://nam11.safelinks.protection.outlook.com/?url=http%3A%2F%2Finsp.memberclicks.net%2Fmessage2%2Flink%2F431312ce-6cb9-4438-af75-1039416b4f64%2F1&data=04%7C01%7Ccarl.panetta%40stjude.org%7Cf9208de0462c4b5f50b908d94604c4d5%7C22340fa892264871b677d3b3e377af72%7C0%7C0%7C637617808589355430%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=eIqf94bFbL%2Bhd%2FbOKPROk30D1R6TYX9JnIEtZOuJyuw%3D&reserved=0) For additional details about the MCS SIG webinars visit: https://nam11.safelinks.protection.outlook.com/?url=http%3A%2F%2Finsp.memberclicks.net%2Fmessage2%2Flink%2F431312ce-6cb9-4438-af75-1039416b4f64%2F2&data=04%7C01%7Ccarl.panetta%40stjude.org%7Cf9208de0462c4b5f50b908d94604c4d5%7C22340fa892264871b677d3b3e377af72%7C0%7C0%7C637617808589365386%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=uEiC5QN8zb6ygT2RWvb%2FmyBmzhxbnNnkn8Q%2B6ccJV34%3D&reserved=0 For information about the MCS SIG visit: https://nam11.safelinks.protection.outlook.com/?url=http%3A%2F%2Finsp.memberclicks.net%2Fmessage2%2Flink%2F431312ce-6cb9-4438-af75-1039416b4f64%2F3&data=04%7C01%7Ccarl.panetta%40stjude.org%7Cf9208de0462c4b5f50b908d94604c4d5%7C22340fa892264871b677d3b3e377af72%7C0%7C0%7C637617808589375344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=Wu%2FeGXrUjZW1KG53MWjnzJzQPPWyzirdaCa8ldtWwBY%3D&reserved=0