Hi All,
I am writing a paper on some C language code I have written that does FOCE.
I want to write a few sentences about the history of NONMEM but I'm not 100%
sure it is correct.
Can someone knowledgeable give me some feedback on this?
"NONMEM software was developed at USCF in the late 1970s and became the
de-facto industry standard when the first-order-conditional estimation with
interaction (FOCE-I) method reaching wide use in the field. NONMEM was open
source until version 5 when the rights were obtained by Icon PLC and it became
encrypted-source. The investment of Icon PLC has resulted in considerable
NONMEM development with many bug-fixes and new features available in current
version 7.5.1. "
Warm regards,
Douglas Eleveld
________________________________
Historical question
Personally I don’t think it was the use of FOCEI that led to NONMEM taking off,
it was that you could run it on personal computers, which were just starting to
be powerful enough to handle to computational load. This was back when
computers had numbers for names, like 386 and 486. I think this started with
NONMEM IV.
There was a history of NONMEM webpage that Icon maintained, but when I checked
today, it no longer looks like it is functional.
https://nonmem.iconplc.com/nonmem_history/NONMEM_history4.pdf
Pete Bonate
Peter Bonate, PhD
Suzerain, New Technologies
Early Development
Astellas
2375 Waterview Drive
Northbrook, IL 60062
[email protected]<mailto:[email protected]>
(224) 619-4901
Quoted reply history
From: [email protected] <[email protected]> On Behalf Of
Eleveld, DJ
Sent: Wednesday, December 4, 2024 5:39 AM
To: nmusers <[email protected]>
Subject: [NMusers] Historical question
Hi All, I am writing a paper on some C language code I have written that does
FOCE. I want to write a few sentences about the history of NONMEM but I’m not
100% sure it is correct. Can someone knowledgeable give me some feedback on
this?
Hi All,
I am writing a paper on some C language code I have written that does FOCE.
I want to write a few sentences about the history of NONMEM but I’m not 100%
sure it is correct.
Can someone knowledgeable give me some feedback on this?
“NONMEM software was developed at USCF in the late 1970s and became the
de-facto industry standard when the first-order-conditional estimation with
interaction (FOCE-I) method reaching wide use in the field. NONMEM was open
source until version 5 when the rights were obtained by Icon PLC and it became
encrypted-source. The investment of Icon PLC has resulted in considerable
NONMEM development with many bug-fixes and new features available in current
version 7.5.1. ”
Warm regards,
Douglas Eleveld
________________________________
Hi Douglas,
On top of this, it might be the encryption only started with version 7. I remember looking at the FOCE code myself, the earliest version I installed was 5 so that one was open. I believe 6 was open as well, perhaps someone can confirm that.
Good luck with your paper!
Jeroen
http://pd-value.com
[email protected]
@PD_value
+31 6 23118438
-- More value out of your data!
Quoted reply history
On 04-12-2024 15:41, Bonate, Peter wrote:
> Personally I don’t think it was the use of FOCEI that led to NONMEM taking off, it was that you could run it on personal computers, which were just starting to be powerful enough to handle to computational load. This was back when computers had numbers for names, like 386 and 486. I think this started with NONMEM IV.
>
> There was a history of NONMEM webpage that Icon maintained, but when I checked today, it no longer looks like it is functional.
>
> https://nonmem.iconplc.com/nonmem_history/NONMEM_history4.pdf
>
> Pete Bonate
>
> *Peter Bonate, PhD*
>
> Suzerain, New Technologies
>
> Early Development
>
> Astellas
>
> 2375 Waterview Drive
>
> Northbrook, IL 60062
>
> [email protected] <mailto:[email protected]>
>
> (224) 619-4901
>
> *From:* [email protected] < [email protected] > *On Behalf Of *Eleveld, DJ
>
> *Sent:* Wednesday, December 4, 2024 5:39 AM
> *To:* nmusers <[email protected]>
> *Subject:* [NMusers] Historical question
>
> Hi All, I am writing a paper on some C language code I have written that does FOCE. I want to write a few sentences about the history of NONMEM but I’m not 100% sure it is correct. Can someone knowledgeable give me some feedback on this?
>
> Hi All,
>
> I am writing a paper on some C language code I have written that does FOCE.
>
> I want to write a few sentences about the history of NONMEM but I’m not 100% sure it is correct.
>
> Can someone knowledgeable give me some feedback on this?
>
> “NONMEM software was developed at USCF in the late 1970s and became the de-facto industry standard when the first-order-conditional estimation with interaction (FOCE-I) method reaching wide use in the field. NONMEM was open source until version 5 when the rights were obtained by Icon PLC and it became encrypted-source. The investment of Icon PLC has resulted in considerable NONMEM development with many bug-fixes and new features available in current version 7.5.1. ”
>
> Warm regards,
>
> Douglas Eleveld
>
> ------------------------------------------------------------------------
>
>
The link still works, but there are sometimes security filters that prevent
successful connection. Access the link first:
https://nonmem.iconplc.com/nonmem_history
Then click on the nonmem_history4.pdf file for the download.
Clarifying one item in Douglas Elevald's e-mail : Rights were obtained by ICON
Plc as of NONMEM VI, and NONMEM 7.1 was the first version in which code was
encrypted.
Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
731 Arbor way, suite 100
Blue Bell, PA 19422
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected]<mailto:[email protected]>
http://www.iconplc.com/
Quoted reply history
From: [email protected] <[email protected]> On Behalf Of
Bonate, Peter
Sent: Wednesday, December 4, 2024 6:42 AM
To: Eleveld, DJ <[email protected]>; nmusers <[email protected]>
Subject: [EXTERNAL] [NMusers] RE: Historical question
Personally I don't think it was the use of FOCEI that led to NONMEM taking off,
it was that you could run it on personal computers, which were just starting to
be powerful enough to handle to computational load. This was back when
computers had numbers for names, like 386 and 486. I think this started with
NONMEM IV.
There was a history of NONMEM webpage that Icon maintained, but when I checked
today, it no longer looks like it is functional.
https://nonmem.iconplc.com/nonmem_history/NONMEM_history4.pdf
Pete Bonate
Peter Bonate, PhD
Suzerain, New Technologies
Early Development
Astellas
2375 Waterview Drive
Northbrook, IL 60062
[email protected]<mailto:[email protected]>
(224) 619-4901
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> On Behalf
Of Eleveld, DJ
Sent: Wednesday, December 4, 2024 5:39 AM
To: nmusers <[email protected]<mailto:[email protected]>>
Subject: [NMusers] Historical question
Hi All, I am writing a paper on some C language code I have written that does
FOCE. I want to write a few sentences about the history of NONMEM but I'm not
100% sure it is correct. Can someone knowledgeable give me some feedback on
this?
Hi All,
I am writing a paper on some C language code I have written that does FOCE.
I want to write a few sentences about the history of NONMEM but I'm not 100%
sure it is correct.
Can someone knowledgeable give me some feedback on this?
"NONMEM software was developed at USCF in the late 1970s and became the
de-facto industry standard when the first-order-conditional estimation with
interaction (FOCE-I) method reaching wide use in the field. NONMEM was open
source until version 5 when the rights were obtained by Icon PLC and it became
encrypted-source. The investment of Icon PLC has resulted in considerable
NONMEM development with many bug-fixes and new features available in current
version 7.5.1. "
Warm regards,
Douglas Eleveld
________________________________