AUC calculations

3 messages 3 people Latest: Feb 15, 2007

AUC calculations

From: Navin Goyal Date: February 15, 2007 technical
Hello everyone, As a part of the simulations I was trying to perform using nonmem, I have a pkpd model. I have a Pharmacodynamic endpoint and was wondering if I could integrate the area under the curve of this endpoint for some time period, (say like AUC for this effect for last 24 hrs ) I guess i could do it in excel (or someone suggested me using SAS). Could I do this in NONMEM? any help would be appreciated. Thanks Navin

RE: AUC calculations

From: Mark Peterson Date: February 15, 2007 technical
Hi Navin, In SAAM2 this can be done with an additional compartment that aggregates the concentration measurements over time. This provides a real-time AUC estimate. If you are working in differential equations in NONMEM you should be able to apply the same approach and read the values out into a table. Cheers, Mark Mark C. Peterson Amgen, Inc. One Amgen Center Drive M.S. 28-3-B Thousand Oaks, CA 91320 Office: 805.447.7222 Cell: 805.300.0978 _____
Quoted reply history
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of navin goyal Sent: Thursday, February 15, 2007 9:53 AM To: [email protected] Subject: [NMusers] AUC calculations Hello everyone, As a part of the simulations I was trying to perform using nonmem, I have a pkpd model. I have a Pharmacodynamic endpoint and was wondering if I could integrate the area under the curve of this endpoint for some time period, (say like AUC for this effect for last 24 hrs ) I guess i could do it in excel (or someone suggested me using SAS). Could I do this in NONMEM? any help would be appreciated. Thanks Navin

Re: AUC calculations

From: David H Salinger Date: February 15, 2007 technical
Navin, If you are using an N-1 ODE model, and want the area under the compartment 1 concentration-time curve, add a differential equation of the form: DADT(N)= A(1)/V1 Then, A(N) provides the area under the concentration-time curve for compartment 1. (If you do not have an ODE model, I would probably integrate the concentration curve by hand and simply compute in NONMEM.) I hope this helps, David Salinger Resource facility for Population Kinetics (RFPK) Dept. of Bioenginerring, University of Washington, Seattle
Quoted reply history
On Thu, 15 Feb 2007, navin goyal wrote: > Hello everyone, > As a part of the simulations I was trying to perform using nonmem, I have a > pkpd model. > > I have a Pharmacodynamic endpoint and was wondering if I could integrate the > area under the curve of this endpoint for some time period, > (say like AUC for this effect for last 24 hrs ) > > I guess i could do it in excel (or someone suggested me using SAS). > > Could I do this in NONMEM? any help would be appreciated. > > Thanks > > Navin