RE: AUC calculations
Hi Navin,
In SAAM2 this can be done with an additional compartment that aggregates the
concentration measurements over time. This provides a real-time AUC
estimate. If you are working in differential equations in NONMEM you should
be able to apply the same approach and read the values out into a table.
Cheers,
Mark
Mark C. Peterson
Amgen, Inc.
One Amgen Center Drive
M.S. 28-3-B
Thousand Oaks, CA 91320
Office: 805.447.7222
Cell: 805.300.0978
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Quoted reply history
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of navin goyal
Sent: Thursday, February 15, 2007 9:53 AM
To: [email protected]
Subject: [NMusers] AUC calculations
Hello everyone,
As a part of the simulations I was trying to perform using nonmem, I have a
pkpd model.
I have a Pharmacodynamic endpoint and was wondering if I could integrate the
area under the curve of this endpoint for some time period,
(say like AUC for this effect for last 24 hrs )
I guess i could do it in excel (or someone suggested me using SAS).
Could I do this in NONMEM? any help would be appreciated.
Thanks
Navin