Re: AUC calculations
Navin,
If you are using an N-1 ODE model, and want the area under the compartment 1
concentration-time curve, add a differential equation of the form:
DADT(N)= A(1)/V1
Then, A(N) provides the area under the concentration-time curve for compartment
1.
(If you do not have an ODE model, I would probably integrate the concentration
curve by hand and simply compute in NONMEM.)
I hope this helps,
David Salinger
Resource facility for Population Kinetics (RFPK)
Dept. of Bioenginerring,
University of Washington, Seattle
Quoted reply history
On Thu, 15 Feb 2007, navin goyal wrote:
> Hello everyone,
> As a part of the simulations I was trying to perform using nonmem, I have a
> pkpd model.
>
> I have a Pharmacodynamic endpoint and was wondering if I could integrate the
> area under the curve of this endpoint for some time period,
> (say like AUC for this effect for last 24 hrs )
>
> I guess i could do it in excel (or someone suggested me using SAS).
>
> Could I do this in NONMEM? any help would be appreciated.
>
> Thanks
>
> Navin