From: Youngjin Moon ymoon2@acsu.buffalo.edu
Subject: [NMusers] ADVAN6..
Date: Wed, 28 Jun 2006 11:27:00 -0400
Dear All,
Hello.. I am very beginner of NONMEM..
I am trying to change a code which previous employee made. It is PK-PD
model. Two compartment PK model with two biomarkers. He used ADVAN6
TOL=3 as $SUBROUTINE. CMT1= depot, CMT2=plasma,
CMT3=peripheral, CMT4= biomarkerA, CMT5=biomarkerB.
And he used
S2=V2
S4=1
S5=1
F4=bioA ;DEFINING INITIAL CONDITION FOR CMT=4
F5=bioB ;DEFINING INITIAL CONDITION FOR CMT=5
In my case I need to change to one compartment model.
I learned in class that with ADVAN1-4 CMT number is designated (like
CMT 2= central in ADVAN2). But I don't have ADVAN6 information.
My question is..
If I don't need peripheral compartment, can I use CMT1= depot,
CMT2=plasma, CMT3= biomarkerA, CMT4=biomarkerB, and change to
S2=V2
S3=1
S4=1
F3=bioA ;DEFINING INITIAL CONDITION FOR CMT=3
F4=bioB ;DEFINING INITIAL CONDITION FOR CMT=4
Or, do I have to keep those number without CMT 3?
Thanks a lot!!!
Youngjin
Youngjin Moon
544 Hochstetter Hall
Department of Pharmaceutical Sciences
School of Pharmacy and Pharmaceutical Sciences
University at Buffalo
State University of New York
Buffalo, NY 14260-1200
ADVAN6..
From: Elodie.Plan@sanofi-aventis.com
Subject: RE: [NMusers] ADVAN6..
Date: Wed, 28 Jun 2006 18:53:08 +0200
Dear Yougjin,
I am also a very beginner...
but it seems to me that your solution is right!
CMT1= depot, CMT2=plasma, CMT3= biomarkerA, CMT4=biomarkerB, yes.
so you are going to have got 1 central compartment + a depot,
so as parameters: ka between the two, CL from the central, and V for the central,
that s why I don't think you can write V2.
the scale seemed to be on the peripheral compartment which you have removed,
you can either write only S3=1 S4=1, either add S1=V.
about the subroutine, advan 6 includes a peripheral compartment,
advan 2 (trans 2) might be better adapted,
but because of biomarkers, I don't know...
Good luck, hope you'll get other advices!
Elodie Plan
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