Re: ERROR -M2 vpc run

On Sat, Mar 23, 2024, 7:22 PM Mohd Rahimi <[email protected]> wrote: > Dear Simbarashe, > > I have tried to remove METHOD= COND before but an error popped out when I > wanted to rerun the model. > > AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. > > 274 $ESTIMATION: METHOD=COND NEEDED WITH LAPLACIAN OPTION. > > > Mohd Rahimi Muda > > > > On Sun, Mar 24, 2024 at 7:09 AM Simbarashe Peter Zvada < > [email protected]> wrote: > >> Dear Mohd, >> >> Do you need METHOD=1 (COND) under $Estimation when you use LAPLACIAN? >> >> I could be wrong, but just remove it and leave for defaults. >> >> Thank you, >> Simba >> >> >> >> >> >> >> >> >> On Sat, Mar 23, 2024, 4:56 PM Mohd Rahimi <[email protected]> wrote: >> >>> Dear NONMEM user, >>> >>> I tried to run a VPC for M2 BQL method by using the code as stated below: >>> >>> ;M2 - Likelihood assumes all values are censored at LLOQ ‘YLO’ >>> >>> >>> >>> >>> >>> >>> >>> >>> * SD = SQRT(1 + THETA(4)**F**2) YLO=LOG(LLOQ) IPRED=F W=SD IRES = >>> DV-IPRED IWRES = IRES/W Y = F + SD*EPS(1)* >>> >>> >>> *$ESTIMATION METHOD=COND LAPLACIAN INTER NUMERICAL NOABORT SLOW NSIG=2 >>> SIGL=9 MAXEVAL=9999 PRINT=1* >>> >>> But I got this kind of error message from NONMEM >>> >>> >>> >>> * AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. 585 LAPLACIAN METHOD >>> IS REQUIRED WHEN YLO, YUP, CTLO, OR CTUP IS USED.* >>> >>> Any thoughts on how to solve this? >>> >>> Thank you >>> >>> -- >>> *Mohd Rahimi Muda* >>> >>