ERROR -M2 vpc run
Dear NONMEM user,
I tried to run a VPC for M2 BQL method by using the code as stated below:
;M2 - Likelihood assumes all values are censored at LLOQ ‘YLO’
* SD = SQRT(1 + THETA(4)**F**2) YLO=LOG(LLOQ) IPRED=F W=SD IRES =
DV-IPRED IWRES = IRES/W Y = F + SD*EPS(1)*
*$ESTIMATION METHOD=COND LAPLACIAN INTER NUMERICAL NOABORT SLOW NSIG=2
SIGL=9 MAXEVAL=9999 PRINT=1*
But I got this kind of error message from NONMEM
* AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. 585 LAPLACIAN METHOD IS
REQUIRED WHEN YLO, YUP, CTLO, OR CTUP IS USED.*
Any thoughts on how to solve this?
Thank you
--
*Mohd Rahimi Muda*