ERROR -M2 vpc run

From: Mohd Rahimi Date: March 23, 2024 technical Source: mail-archive.com
Dear NONMEM user, I tried to run a VPC for M2 BQL method by using the code as stated below: ;M2 - Likelihood assumes all values are censored at LLOQ ‘YLO’ * SD = SQRT(1 + THETA(4)**F**2) YLO=LOG(LLOQ) IPRED=F W=SD IRES = DV-IPRED IWRES = IRES/W Y = F + SD*EPS(1)* *$ESTIMATION METHOD=COND LAPLACIAN INTER NUMERICAL NOABORT SLOW NSIG=2 SIGL=9 MAXEVAL=9999 PRINT=1* But I got this kind of error message from NONMEM * AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. 585 LAPLACIAN METHOD IS REQUIRED WHEN YLO, YUP, CTLO, OR CTUP IS USED.* Any thoughts on how to solve this? Thank you -- *Mohd Rahimi Muda*
Mar 23, 2024 Mohd Rahimi ERROR -M2 vpc run
Mar 23, 2024 Simbarashe Peter Zvada Re: ERROR -M2 vpc run
Mar 24, 2024 Simbarashe Peter Zvada Re: ERROR -M2 vpc run
Mar 24, 2024 Leonid Gibiansky Re: ERROR -M2 vpc run