Re: ERROR -M2 vpc run
Dear Mohd,
Do you need METHOD=1 (COND) under $Estimation when you use LAPLACIAN?
I could be wrong, but just remove it and leave for defaults.
Thank you,
Simba
Quoted reply history
On Sat, Mar 23, 2024, 4:56 PM Mohd Rahimi <[email protected]> wrote:
> Dear NONMEM user,
>
> I tried to run a VPC for M2 BQL method by using the code as stated below:
>
> ;M2 - Likelihood assumes all values are censored at LLOQ ‘YLO’
>
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> * SD = SQRT(1 + THETA(4)**F**2) YLO=LOG(LLOQ) IPRED=F W=SD IRES =
> DV-IPRED IWRES = IRES/W Y = F + SD*EPS(1)*
>
>
> *$ESTIMATION METHOD=COND LAPLACIAN INTER NUMERICAL NOABORT SLOW NSIG=2
> SIGL=9 MAXEVAL=9999 PRINT=1*
>
> But I got this kind of error message from NONMEM
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>
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> * AN ERROR WAS FOUND IN THE CONTROL STATEMENTS. 585 LAPLACIAN METHOD IS
> REQUIRED WHEN YLO, YUP, CTLO, OR CTUP IS USED.*
>
> Any thoughts on how to solve this?
>
> Thank you
>
> --
> *Mohd Rahimi Muda*
>