RE: Specify full OMEGA matrix for simulation
Hi Philip,
An exact alternative would be to use this:
$OMEGA BLOCK(2) FIX
0.078
0 0.02
$OMEGA BLOCK(1) FIX
0
Note – I have not tested this but if BLOCK(2) FIX works then BLOCK(1) FIX
should work.
Best wishes,
Nick
--
Nick Holford, Professor Emeritus Clinical Pharmacology, MBChB, FRACP
mobile:NZ+64(21)46 23 53 ; FR+33(6)62 32 46 72
email: [email protected]<mailto:[email protected]>
web: http://holford.fmhs.auckland.ac.nz/
Quoted reply history
From: [email protected] <[email protected]> On Behalf Of
Philip Harder Delff
Sent: Thursday, July 6, 2023 1:10 PM
To: Leonid Gibiansky <[email protected]>; [email protected]
Subject: Re: [NMusers] Specify full OMEGA matrix for simulation
Thanks Leonid, that's pretty enough for me.
Best,
Philip
On July 6, 2023 8:01:41 AM ADT, Leonid Gibiansky
<[email protected]<mailto:[email protected]>> wrote:
Looks like a bug.
Workaround is to use a very small diagonal value (1E-30)
Leonid
On 7/6/2023 6:01 AM, Philip Harder Delff wrote:
Hi all,
I am trying to specify a full OMEGA matrix for simulation purpose. I get issues
because some diagonals are zero and some are positive. If I write
$OMEGA BLOCK(3) FIX
0.078
0 0.02
0 0 0
I get this error:
AN ERROR WAS FOUND ON LINE 34 AT THE APPROXIMATE POSITION NOTED:
0 0 0
224 A VARIANCE IS ZERO, BUT THE BLOCK IS NOT FIXED TO ZERO.
I know I could do:
$OMEGA BLOCK(2) FIX
0.078
0 0.02
$OMEGA FIX
0
However, that would be complicated to generate programmatically. Anyway I can
tell Nonmem to use a specified OMEGA matrix as is for a simulation?
Thank you,
Philip