Specify full OMEGA matrix for simulation

From: Philip Harder Delff Date: July 06, 2023 technical Source: mail-archive.com
Hi all, I am trying to specify a full OMEGA matrix for simulation purpose. I get issues because some diagonals are zero and some are positive. If I write $OMEGA BLOCK(3) FIX 0.078 0 0.02 0 0 0 I get this error: AN ERROR WAS FOUND ON LINE 34 AT THE APPROXIMATE POSITION NOTED: 0 0 0 224 A VARIANCE IS ZERO, BUT THE BLOCK IS NOT FIXED TO ZERO. I know I could do: $OMEGA BLOCK(2) FIX 0.078 0 0.02 $OMEGA FIX 0 However, that would be complicated to generate programmatically. Anyway I can tell Nonmem to use a specified OMEGA matrix as is for a simulation? Thank you, Philip
Jul 06, 2023 Philip Harder Delff Specify full OMEGA matrix for simulation
Jul 06, 2023 Leonid Gibiansky Re: Specify full OMEGA matrix for simulation
Jul 06, 2023 Nick Holford RE: Specify full OMEGA matrix for simulation
Jul 07, 2023 Philip Harder Delff Re: Specify full OMEGA matrix for simulation