RE: [EXTERNAL] Continuation of "What does "Second Error signal from LINV1PD: 129"

From: Leonid Gibiansky <[email protected]> Sent: Friday, September 16, 2022 5:42 PM To: Bauer, Robert <[email protected]>; nmusers <[email protected]> Subject: Re: [EXTERNAL] [NMusers] Continuation of "What does "Second Error signal from LINV1PD: 129" Thank you, Bob! Ctl-T command is not working in parallel mode (on my Windows 10 system) but it worked perfectly fine in the single-processor mode. Thank you Leonid On 9/16/2022 5:21 PM, Bauer, Robert wrote: > Leonid: > You can enter ctrl-T to see OFV outputs of each subject, and you can > note which of the subjects is issuing an LNV1PD: 129 error. The error > issues first, then the subject number is shown. > > Robert J. Bauer, Ph.D. > Senior Director > Pharmacometrics R&D > ICON Early Phase > 731 Arbor way, suite 100 > Blue Bell, PA 19422 > Office: (215) 616-6428 > Mobile: (925) 286-0769 > [email protected]<mailto:[email protected]> > <mailto:[email protected]> > http://www.iconplc.com > http://www.iconplc.com http://www.iconplc.com > > -----Original Message----- > From: [email protected]<mailto:[email protected]> > <mailto:[email protected]> > <[email protected]<mailto:[email protected]>> On Behalf > Of Leonid Gibiansky > Sent: Friday, September 16, 2022 12:57 PM > To: nmusers <[email protected]<mailto:[email protected]>> > Subject: [EXTERNAL] [NMusers] Continuation of "What does "Second Error > signal from LINV1PD: 129" > > Hi Nick and Bob, > > There was a thread in 2010 about LINV1PD: 129 error, see below. > Is it possible to get ID(s) of the subject(s) with the problem or > extract any other useful information to debug the issue? I am using > ADVAN5 with LAPLACIAN option (with PROTECT), are there any tricks that > would help to avoid or debug the problem? The iterations move forward in > spite of multiple error messages that continue to appear through the > whole run, and the model provided the parameters and predictions, and > even completed the covariance step but it would be helpful to find out > what causes the error. > > Thank you > Leonid > > =================================================================== > Nick: > It means that a positive definiteness correction on the eta Hessian > matrix of a particular individual at a particular iteration was not > successful, but NONMEM goes ahead anyway. If it happened on an > intermediate iteration, and the error signal was not continually > repeated, then NONMEM managed to get through the numerical rough spot, > and there is not likely a systematic issue to the problem. > > > Robert J. Bauer, Ph.D. > ______________________________ > Sent: Friday, November 19, 2010 7:16 PM > To: nmusers > Subject: [NMusers] What does "Second Error signal from LINV1PD: 129" > mean? > > > Hi, > I'm using NM7.1.2 > $EST MAX=9990 NOABORT NSIG=3 SIGL=9 PRINT=1 METHOD=CONDITIONAL LAPLACIAN > SLOW $SUBR ADVAN6 TOL=6 Predictions are made using F_FLAG=0 and F_FLAG=1 > > I get this message I have never seen before. It happens with one > particular model that is closely related to others that run Ok. The > model with this error seems to run Ok and produces plausible parameters. > What does this message mean? > > Second Error signal from LINV1PD: 129 > > Nick > > >