RE: [EXTERNAL] Continuation of "What does "Second Error signal from LINV1PD: 129"
Leonid:
You can enter ctrl-T to see OFV outputs of each subject, and you can note which
of the subjects is issuing an LNV1PD: 129 error. The error issues first, then
the subject number is shown.
Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
731 Arbor way, suite 100
Blue Bell, PA 19422
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected]
www.iconplc.com
Quoted reply history
-----Original Message-----
From: [email protected] <[email protected]> On Behalf Of
Leonid Gibiansky
Sent: Friday, September 16, 2022 12:57 PM
To: nmusers <[email protected]>
Subject: [EXTERNAL] [NMusers] Continuation of "What does "Second Error signal
from LINV1PD: 129"
Hi Nick and Bob,
There was a thread in 2010 about LINV1PD: 129 error, see below.
Is it possible to get ID(s) of the subject(s) with the problem or extract any
other useful information to debug the issue? I am using
ADVAN5 with LAPLACIAN option (with PROTECT), are there any tricks that would
help to avoid or debug the problem? The iterations move forward in spite of
multiple error messages that continue to appear through the whole run, and the
model provided the parameters and predictions, and even completed the
covariance step but it would be helpful to find out what causes the error.
Thank you
Leonid
===================================================================
Nick:
It means that a positive definiteness correction on the eta Hessian matrix of a
particular individual at a particular iteration was not successful, but NONMEM
goes ahead anyway. If it happened on an intermediate iteration, and the error
signal was not continually repeated, then NONMEM managed to get through the
numerical rough spot, and there is not likely a systematic issue to the problem.
Robert J. Bauer, Ph.D.
______________________________
Sent: Friday, November 19, 2010 7:16 PM
To: nmusers
Subject: [NMusers] What does "Second Error signal from LINV1PD: 129"
mean?
Hi,
I'm using NM7.1.2
$EST MAX=9990 NOABORT NSIG=3 SIGL=9 PRINT=1 METHOD=CONDITIONAL LAPLACIAN SLOW
$SUBR ADVAN6 TOL=6 Predictions are made using F_FLAG=0 and F_FLAG=1
I get this message I have never seen before. It happens with one particular
model that is closely related to others that run Ok. The model with this error
seems to run Ok and produces plausible parameters.
What does this message mean?
Second Error signal from LINV1PD: 129
Nick