Re: Assessment of elimination half life of mAb
Dear Leonid,
Many thanks for clearing up my doubt. Can you suggest me any paper to go
into this topic in any depth.
Best,
Niurys
Quoted reply history
El 28/04/2021 19:34, "Leonid Gibiansky" <[email protected]>
escribió:
> There is no such thing as half-life of elimination for the nonlinear drug.
> But one can compute something like half-life:
>
> 1. Half-life of the linear part (defined by CL, V1, V2, Q): this defines
> the half-life at high doses/high concentrations when nonlinear elimination
> is saturated.
>
> 2. Washout time: for the linear drug, 5 half-lives can be used to define
> washout time. During this time, concentrations drop approximately 2^5=32
> times. So one can simulate the desired dosing (single dose or steady
> state), find the time from Cmax to Cmax/32 and call it washout time (or
> time to Cmax/64 to be conservative)
>
> Thanks
> Leonid
>
>
> On 4/28/2021 5:17 PM, Niurys.CS wrote:
>
>> Dear all
>> I need some help to assess the elimination half life of a monoclonal
>> antibody.
>> The model that describes the data is a QSS aproximation of TMDD with Rmax
>> constant. The model includes two binding process of mAb to its target: in
>> central and peripheral compartments.
>> Is there any specific equation to calcule lambda z and the elimination
>> half life for each of the TMDD aproximations?
>> Thanks
>> Niurys
>>
>>