RE: $ABBR REPLACE Limitations?

From: [email protected] [mailto:[email protected]] On Behalf Of Bill Denney Sent: Tuesday, January 23, 2018 4:40 PM To: Luann Phillips Cc: nmusers Subject: RE: [NMusers] $ABBR REPLACE Limitations? Hi Luann, I’m not having similar problems with other parameters with >6 characters. I had a similar issue with ALAG1, so I think that there are limitations on what types of variables you can remap. (Perhaps Allison or Bob could confirm?) Thanks, Bill From: Luann Phillips [mailto:[email protected]<mailto:[email protected]>] Sent: Tuesday, January 23, 2018 3:51 PM To: Bill Denney <[email protected]<mailto:[email protected]>> Cc: nmusers <[email protected]<mailto:[email protected]>> Subject: Re: [NMusers] $ABBR REPLACE Limitations? Bill, I know at one time NM had a bug (haven't checked to see if it has been fixed) that would cause variables with the first 6 characters the same to be interpreted as the same variable even when later characters differed. I wonder if this is a similar issue? Have you tried a shorter variable name, such as FCD1GUT=F1? Just a thought, Luann ________________________________ From: "Bill Denney" <[email protected]<mailto:[email protected]>> To: "nmusers" <[email protected]<mailto:[email protected]>> Sent: Tuesday, January 23, 2018 2:15:32 PM Subject: [NMusers] $ABBR REPLACE Limitations? Hi, I’m working in NONMEM 7.4.1 with a model where I need to track 4 drugs simultaneously. To increase the model quality, I’m making heavy use of $ABBR REPLACE to keep track of THETA, ETA, and CMT numbers. I traced an issue with my model where there was no gradient on a bioavailability term to the fact that this substitution didn’t seem to be working: $ABBR REPLACE FCMTD1GUT=F1 … $PK … FCMTD1GUT = THETA(1) FCMTD1GUT didn’t seem to be effectively replaced to F1, so the bioavailability parameters had no effect. When I changed it to just directly name F1, it worked as expected. $PK … F1 = THETA(1) It’s not obvious from the $ABBR REPLACE section of the manual that this is a limitation of $ABBR REPLACE. Is this an issue or am I missing something? Thanks, Bill ________________________________ http://www.humanpredictions.com/[Image removed by sender. Human Predictions http://www.humanpredictions.com/ http://www.humanpredictions.com/William S. Denney, PhD Chief Scientist, Human Predictions LLC +1-617-899-8123 [email protected]<mailto:[email protected]> This e-mail communication is confidential and is intended only for the individual(s) or entity named above and others who have been specifically authorized to receive it. If you are not the intended recipient, please do not read, copy, use or disclose the contents of this communication to others. Please notify the sender that you have received this e-mail in error by replying to the e-mail or by calling +1-617-899-8123. Please then delete the e-mail and any copies of it. Thank you.