Re: $ABBR REPLACE Limitations?

> On Jan 24, 2018, at 00:43, Bauer, Robert <[email protected]> wrote: > > This bug has been fixed since NONMEM 7.4 > > > Bug #1, nm730_bug_list.pdf in https://nonmem.iconplc.com/nonmem730 > Two variables with names longer than six characters, and identical in the > first six characters, defined in $PK, and used in $DES, will be seen as the > same variable. Use variable names that differ in the first six characters. > This occurs in NONMEM 7.1.0, 7.1.2, 7.2.0, and 7.3.0. A workaround is to > move all assignment statements for variables whose first 6 characters match > to $DES. > > Robert J. Bauer, Ph.D. > Senior Director > Pharmacometrics R&D > ICON Early Phase > 820 W. Diamond Avenue > Suite 100 > Gaithersburg, MD 20878 > Office: (215) 616-6428 > Mobile: (925) 286-0769 > [email protected] > www.iconplc.com > > From: [email protected] [mailto:[email protected]] On > Behalf Of Bill Denney > Sent: Tuesday, January 23, 2018 4:40 PM > To: Luann Phillips > Cc: nmusers > Subject: RE: [NMusers] $ABBR REPLACE Limitations? > > Hi Luann, > > I’m not having similar problems with other parameters with >6 characters. I > had a similar issue with ALAG1, so I think that there are limitations on what > types of variables you can remap. (Perhaps Allison or Bob could confirm?) > > Thanks, > > Bill > > From: Luann Phillips [mailto:[email protected]] > Sent: Tuesday, January 23, 2018 3:51 PM > To: Bill Denney <[email protected]> > Cc: nmusers <[email protected]> > Subject: Re: [NMusers] $ABBR REPLACE Limitations? > > Bill, > > I know at one time NM had a bug (haven't checked to see if it has been fixed) > that would cause variables with the first 6 characters the same to be > interpreted as the same variable even when later characters differed. I > wonder if this is a similar issue? > Have you tried a shorter variable name, such as FCD1GUT=F1? > > Just a thought, > Luann > > From: "Bill Denney" <[email protected]> > To: "nmusers" <[email protected]> > Sent: Tuesday, January 23, 2018 2:15:32 PM > Subject: [NMusers] $ABBR REPLACE Limitations? > > Hi, > > I’m working in NONMEM 7.4.1 with a model where I need to track 4 drugs > simultaneously. To increase the model quality, I’m making heavy use of $ABBR > REPLACE to keep track of THETA, ETA, and CMT numbers. I traced an issue with > my model where there was no gradient on a bioavailability term to the fact > that this substitution didn’t seem to be working: > > $ABBR REPLACE FCMTD1GUT=F1 > … > $PK > … > FCMTD1GUT = THETA(1) > > FCMTD1GUT didn’t seem to be effectively replaced to F1, so the > bioavailability parameters had no effect. When I changed it to just directly > name F1, it worked as expected. > > $PK > … > F1 = THETA(1) > > It’s not obvious from the $ABBR REPLACE section of the manual that this is a > limitation of $ABBR REPLACE. Is this an issue or am I missing something? > > Thanks, > > Bill > > <image001.jpg>William S. Denney, PhD > Chief Scientist, Human Predictions LLC > +1-617-899-8123 > [email protected] > This e-mail communication is confidential and is intended only for the > individual(s) or entity named above and others who have been specifically > authorized to receive it. If you are not the intended recipient, please do > not read, copy, use or disclose the contents of this communication to others. > Please notify the sender that you have received this e-mail in error by > replying to the e-mail or by calling +1-617-899-8123. Please then delete the > e-mail and any copies of it. Thank you. > > > >