Re: Time varying volume of distribution implementation

From: M Jamei Sent: Saturday, 23 April 2016 08:30 To: Thorsten Lehr Cc: [email protected] Subject: Re: [NMusers] Time varying volume of distribution implementation Hi Thorsten We have done this in both paediatrics and pregnancy and you may find the following paper useful. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012043/ Changes in individual drug-independent system parameters during virtual paediatric pharmacokinetic trials: introducing time-varying physiology into a paediatric PBPK model. Abduljalil K, et al. AAPS J. 2014. Regards Masoud On 22 Apr 2016, at 22:34, Thorsten Lehr <[email protected]<mailto:[email protected]>> wrote: Dear NMusers, I'm modeling a compound where body weight has a known impact on the volume of distribution. This compound is investigated in pregnant women over a long period (from gestational age of 8 weeks until they give birth). Consequently, the body weight changes over time and I have a decent formula to describe the individual body weight change. The PK model has to be coded by ODEs. Does anyone has experience how to integrate a time varying volume of distribution if differential equations are used? Best regards Thorsten -- Thorsten Lehr, PhD Junior Professor of Clinical Pharmacy Saarland University Campus C2 2 66123 Saarbrücken Germany Office: +49/681/302-70255 Mobile: +49/151/22739489 [email protected]<mailto:[email protected]> http://www.clinicalpharmacy.me