Time varying volume of distribution implementation

Dear NMusers, I'm modeling a compound where body weight has a known impact on the volume of distribution. This compound is investigated in pregnant women over a long period (from gestational age of 8 weeks until they give birth). Consequently, the body weight changes over time and I have a decent formula to describe the individual body weight change. The PK model has to be coded by ODEs. Does anyone has experience how to integrate a time varying volume of distribution if differential equations are used? Best regards Thorsten -- Thorsten Lehr, PhD Junior Professor of Clinical Pharmacy Saarland University Campus C2 2 66123 Saarbrücken Germany Office: +49/681/302-70255 Mobile: +49/151/22739489 [email protected] www.clinicalpharmacy.me