Re: Time varying volume of distribution implementation
Hi Thorsten
We have done this in both paediatrics and pregnancy and you may find the
following paper useful.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012043/
Changes in individual drug-independent system parameters during virtual
paediatric pharmacokinetic trials: introducing time-varying physiology into a
paediatric PBPK model.
Abduljalil K, et al. AAPS J. 2014.
Regards
Masoud
Quoted reply history
On 22 Apr 2016, at 22:34, Thorsten Lehr <[email protected]>
wrote:
Dear NMusers,
I'm modeling a compound where body weight has a known impact on the volume of
distribution. This compound is investigated in pregnant women over a long
period (from gestational age of 8 weeks until they give birth). Consequently,
the body weight changes over time and I have a decent formula to describe the
individual body weight change. The PK model has to be coded by ODEs. Does
anyone has experience how to integrate a time varying volume of distribution if
differential equations are used?
Best regards
Thorsten
--
Thorsten Lehr, PhD
Junior Professor of Clinical Pharmacy
Saarland University
Campus C2 2
66123 Saarbrücken
Germany
Office: +49/681/302-70255
Mobile: +49/151/22739489
[email protected]
www.clinicalpharmacy.me