Re: ASCO and pharmacometrics
Hi Naoto,
I am a clinical oncologist and I attend ASCO every year. I had a poster last
year that was reporting our model of chemotherapy-induced peripheral neuropathy
and the results of simulations to determine a dose-adjustment algorithm.
I think it is likely that your work was underappreciated by the scientific
review committee. Unlike the ACoP and ASCPT meetings, many reviewers would be
unfamiliar with pharmacometrics.
As a community, we should continue submitting our work to these types of
meetings, but I would recommend focusing on the clinical and/or drug
development decisions that were supported by the model rather than the
technical details.
Best regards,
Manish Sharma, MD
Quoted reply history
On Apr 5, 2016, at 8:44 PM, Naoto Hayashi
<[email protected]<mailto:[email protected]>> wrote:
Dear all,
I have a question and appreciate it if somebody can answer to me.
We had submitted an abstract to ASCO annual meeting presentation 2016, and its
contents included a pharmacometrics work of quantitative safety profile
analysis of an anticancer drug. The behave of the safety index time courses is
very unique and its results showed a very high usefulness of this drug. The
abstract also included the table of population PK/PD parameters that expressed
its nature, and it was compared with the similar older drug safety profile and
demonstrated very high safer profile quantitatively.
I have some experiences to publish some articles of population PK/PD work in
several clinical pharmacology journals in the past, and I was so confident for
just a poster presentation in ASCO. However, the judgment was “publication
only”, i.e. just presentation in online but no poster presentation and no
official record of publication officially.
So, my question is whether pharmacometrics work is difficult to be picked up in
ASCO presentation. Or, was my work evaluated to have no worth to be presented
even in poster session because the pharmacometrics works presented in ASCO are
having very high level?
I have never visited ASCO before, and I just want to hear opinions about how
much of importance is considered for pharmacometrics work in ASCO.
Thanks a lot in advance for your comments/thoughts.
Best regards,
Naoto Hayashi
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