Re: Calculation of half life
Santosh,
There is an article that provides the equations that I think you are looking for. Calculating the hybrid (macro) rate constants of a three-compartment mamillary pharmacokinetic model from known micro-rate constants.
Richard Upton
Journal of Pharmacological and Toxicological Methods 49 (2004) pg. 65-68
Best regards,
Luann
Luann Phillips
Director, Pharmacometrics
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Quoted reply history
On Wed, Mar 30, 2016 at 11:40 AM, Santosh wrote:
> Dear all,
> I am looking for ways to calculate t[1/2,lamda,z] the elimination
> phase half life, using a 3-compartment model. ADVAN 12 and TRANS6
> seems to be a way. However, I am using the intercompartment
> clearance and volumes based parameterization, e.g. Q3,V3 etc..
>
> half.life = log(2)/gamma
>
> Could anyone please share NONMEM code to compute the half-life
> based on gamma?
>
> Thanks so much in advance.
>
> Best regards,
> Santosh