RE: Calculation of half life
Santosh
Perhaps a more pertinent question is – Why do you want to know half-life?
Steve
………………………………………………………………………………………………………………………..……………………..………………………………………
Stephen Duffull I Professor of Clinical Pharmacy | Dean
Otago Pharmacometrics Group
New Zealand’s National School of Pharmacy | Te Kura Mātauraka Wai-whakaora
University of Otago | Te Whare Wānanga o Otāgo
Dunedin | Ōtepoti
Ph: 64 3 479 5044
Website | http://www.pharmacometrics.co.nz/
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Santosh
Sent: Thursday, 31 March 2016 4:41 a.m.
To: [email protected]
Subject: [NMusers] Calculation of half life
Dear all,
I am looking for ways to calculate t[1/2,lamda,z] the elimination phase half
life, using a 3-compartment model. ADVAN 12 and TRANS6 seems to be a way.
However, I am using the intercompartment clearance and volumes based
parameterization, e.g. Q3,V3 etc..
half.life = log(2)/gamma
Could anyone please share NONMEM code to compute the half-life based on gamma?
Thanks so much in advance.
Best regards,
Santosh