RE: NM-Tran infer data are single subject when perform simulation
Dear Tommy,
You may also remove the $COV for the simulations.
Best regards,
Jean
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Tommy Li
Sent: Thursday, October 29, 2015 15:04
To: “[email protected]”
Subject: [NMusers] NM-Tran infer data are single subject when perform simulation
Hello
I have population data set that I fitted to a model. However, when I try to use
the exact data set and model to perform simulation, I encounter the situation
where NM-Tran infer the data as single subject. Is there a reason why this
happens? Also, how do I force NM-Tran to infer data as population for
simulation in this case?
To perform simulation I just change from $EST to $SIM. I have done this before
with other model and data set before with no problem. I did the same with
current model.
Here is the beginning and end of my model code:
$INPUT ID PART TRT PTIM PTM2 TM TSLD AMT D FLAG CMT FBQL EVID MDV AGE SEX WGT
HGT BSA DIAB HTN HLIP ETOH SMOK BDAS BSJC BTJC BCRP WBC ALB ALT AST CRCL ACR20
ACR50 ACR70 TIME TIME_ DV DV_ ACR50C ACR50P ACR70C ACR70P KAI CLI VI
$DATA pddataACRTIMECOR.csv IGNORE=@
$SUBROUTINES ADVAN6 TOL=10
$SUBROUTINES OTHER=bivariate.f90
$MODEL NCOMP=3 COMP=DEPOT COMP=CENTRAL COMP=EFFECT
$PK
.....
$ERROR
.....
$THETA
.....
$OMEGA
.....
$EST MAX=8000 PRINT=2 METHOD=1 LAPLACE -2LL SIGL=10 NOHABORT
$COV COMPRESS MATRIX=R PRINT=E UNCONDITIONAL
For simulation, I just change the $EST block to $SIM
$SIM (547676) (523842) ONLYSIM SUBPROBLEMS=1
Thank you
Tommy Li
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