Re: Estimation of ke0 from raw data
Hi Jos,
Why not try the indirect response model instead? The fixed effects are more
interpretable pharmacologically than just using Ke0.
The initial estimate of the first order rate constant of degradation (kout) of
response could be the slope of the decline of the response when plotted with
time.
You can read more in detail as there is lot of literature if you are not
familiar with these models.
Best
Mukul Minocha
Quoted reply history
> On 05-Sep-2015, at 13:43, Lommerse, JPM (Jos) <[email protected]> wrote:
>
> Hi,
>
> I have a data set containing PK concentrations and PD effect.
> When plotting PD as a function of PD a clear anti-clockwise hysteresis
> plot appears.
> I would like to get a (rough) estimate of the PD time delay w.r.t. the PK
> without
> using a compartmental description for the observed PK, even not using
> a polynomal function that fits the PK. The assumption I make is that
> all PD delay can be explained by the delay through an effect compartment.
> I am wondering if methods exist that solely use the raw data to
> calculate such time delays.
>
> Thank you for any comment/suggestion,
>
> Jos
>
> Jos Lommerse
> Modeler Consultant
> Quantitative Solutions BV
> Molenweg 79
> 5349 AC Oss
> The Netherlands
> [email protected]
> +31 412 211102
>
>
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