RE: NM7.2 SAEM with LIKE
Filip:
The $TABLE results are obtained from a "post-hoc" assessment at the best fit
eta values (modal, EBE), regardless of the method used. To evaluate $TABLE
parameters at the conditional mean positions, you may select FNLETA=0.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics, R&D
ICON Development Solutions
7740 Milestone Parkway
Suite 150
Hanover, MD 21076
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: http://www.iconplc.com/
Quoted reply history
________________________________
From: [email protected] [mailto:[email protected]] On
Behalf Of De Ridder, Filip [JRDBE]
Sent: Tuesday, August 07, 2012 10:18 AM
To: [email protected]
Subject: [NMusers] NM7.2 SAEM with LIKE
Dear All,
With NM7.2/SAEM, the root.phi output file contains the conditional means (and
variances) of the individual phi's (mu(i)+eta(i)) - which is great! I found
that the these values can be different from what you get from a $TABLE in more
classical way:
$PRED
MU_1=THETA(1)
K=MU_1+ETA(1)
...
$TABLE K ...
For a some subjects, these are very different, and the ones coming from the
$TABLE are clearly less optimal, yielding a bad individual fit, as judged from
IPRE calculated in $PRED.
I guess one part of the solution is using CPRED and CPREDI - but unfortunately
I cannot use these as I (have to) use LIKELIHOOD in $EST (M3 method for
BLQ-data).
Kind regards,
Filip De Ridder
Janssen R&D, Beerse, Belgium.