NM7.2 SAEM with LIKE
Dear All,
With NM7.2/SAEM, the root.phi output file contains the conditional means
(and variances) of the individual phi's (mu(i)+eta(i)) - which is great!
I found that the these values can be different from what you get from a
$TABLE in more classical way:
$PRED
MU_1=THETA(1)
K=MU_1+ETA(1)
...
$TABLE K ...
For a some subjects, these are very different, and the ones coming from
the $TABLE are clearly less optimal, yielding a bad individual fit, as
judged from IPRE calculated in $PRED.
I guess one part of the solution is using CPRED and CPREDI - but
unfortunately I cannot use these as I (have to) use LIKELIHOOD in $EST
(M3 method for BLQ-data).
Kind regards,
Filip De Ridder
Janssen R&D, Beerse, Belgium.