RE: How to Increase Maximum NO. of Evaluations of Differential Equation in NONMEM 7
If you are using NONMEM 7.2, IMAX can be increased by setting MAXFCN, by
inserting as the first executable line in the control stream file:
$SIZES MAXFCN=1000000000
Keep in mind that as a 4 byte integer, MAXFCN cannot exceed 2**31=2147483648.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: www.icondevsolutions.com
Quoted reply history
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Wenjun
Sent: Wednesday, June 22, 2011 4:53 PM
To: Li Li
Cc: [email protected]
Subject: Re: [NMusers] How to Increase Maximum NO. of Evaluations of
Differential Equation in NONMEM 7
Dear lili,
You can try following code:
" FIRST
" USE PRCOM_INT,ONLY:MITER,METH,IMAX,ISTFLG,INTFLG
" MAIN
" IMAX=10000000000000
Hope it helps.
Wenjun Ni, Ph.D.
Division of Pharmaceutics
College of Pharmacy
The Ohio State University
500 W 12th Ave
Columbus, OH 43210
On Wed, Jun 22, 2011 at 4:17 PM, Li Li <[email protected]> wrote:
> Hi,
>
> I am using ADVAN 6 to do some PKPD modeling and got this error message:
> NUMERICAL DIFFICULTIES WITH INTEGRATION
> ROUTINE.
> MAXIMUM NO. OF EVALUATIONS OF DIFFERENTIAL EQUATIONS, 1000000,
> EXCEEDED.
>
> I know in NONMEM 6 you may use following code to increase maximum number of
> integration of differential equation:
> "FIRST
> " COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5
> " INTEGER IDUM1,IDUM2,IMAX,IDUM4,IDUM5
> " IMAX=100000000
> But in NONMEM 7 it gave error message:
> (WARNING 113) VERBATIM CODE CONTAINS "COMMON". IF THIS IS NOT A
> USER-DEFINED COMMON, IT SHOULD BE REPLACED BY THE APPROPRIATE MODULE.
> CREATING MUMODEL ROUTINE...
>
> Thus, how can I increase maximum number of integration of differential
> equation in NONMEM 7?
>
> Thank you.
>
> lili