Re: How to Increase Maximum NO. of Evaluations of Differential Equation in NONMEM 7

Li Li, If this is the model that you have described previously, you may want to try ADVAN8 or ADVAN13. With the cusps that the on/off nature of your rate constant a stiff diff. eq. solver may perform better. best regards, Luann Phillips Director PK/PD Cognigen Corporation Li Li wrote: > Hi, > > I am using ADVAN 6 to do some PKPD modeling and got this error message: NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE. MAXIMUM NO. OF EVALUATIONS OF DIFFERENTIAL EQUATIONS, 1000000, EXCEEDED. I know in NONMEM 6 you may use following code to increase maximum number of integration of differential equation: > > "FIRST > " COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5 > " INTEGER IDUM1,IDUM2,IMAX,IDUM4,IDUM5 > " IMAX=100000000 > But in NONMEM 7 it gave error message: > (WARNING 113) VERBATIM CODE CONTAINS "COMMON". IF THIS IS NOT A > USER-DEFINED COMMON, IT SHOULD BE REPLACED BY THE APPROPRIATE MODULE. > CREATING MUMODEL ROUTINE... > > Thus, how can I increase maximum number of integration of differential equation in NONMEM 7? Thank you. lili