RE: Does inter-CPU variability exist in NONMEM??

Dear Chungam - You are not alone. A few years ago, I ran into a similar problem in comparing results (probably with NONMEM V at that time) from different computers. I was using an identical compiler on each, as well as identical compile settings (this is worth checking in your situation). Even the operating system was the same (Windows XP Professional), as I recall. Still I was getting subtle and not so subtle differences, including convergence vs. non-convergence. The only difference I could identify was, in fact, the machine on which the problem was run. I assumed at the time that the differences were down to small differences in the way each CPU handled floating point calculations (both were Intel, however; one was a laptop, the other a desktop). I also suspect that the model I was working on was not super robust, so that small differences translated into successful or non-successful convergence. Anyway, what you are seeing is not unheard of. Good luck! __________________________________________ Kevin Dykstra, PhD, FCP President/CEO Description: QPharmetra_noTag_FA little.png +1 978.655.1943 (O) +1 978.289.2987 (M) <mailto:[email protected]> [email protected] | http://qPharmetra.com http://qPharmetra.com ____________________________________________________________________________ ______________________________ This e-mail communication is confidential and is intended only for the individual(s) or entity named above and others who have been specifically authorized to receive it. If you are not the intended recipient, please do not read, copy, use or disclose the contents of this communication to others. Please notify the sender that you have received this e-mail in error by replying to the e-mail or by telephoning 978-655-1943. Please then delete the e-mail and any copies of it. Thank you.