Does inter-CPU variability exist in NONMEM??
Dear all
I’m a newbie in this field practicing NONMEM using a few sets of bioavailabilty
data.
2days before, I managed to make a model and got to get some parameters. Though
I couldn’t
sure about it due to my poor background, they(parameters) were quite similar to
those in a paper.
Anyway, the thing was, the results were not constant in a single NMTRAN file.
I’ve struggled for
a few days figuring out what the problem was, but I couldn’t get the first
result. After I had run the same
control file with the same data in another PC, surprisingly, I could find that
the parameters were not the same
as those from the prior PC. This had AMD X2 250/2G DDR2 DRAM(Samsung)/windows 7
32bit and
that had Intel i870/8G DDR3 DRAM(Samsung)/windows vista 32bit. Both had NONMEM
7/gfortran(in NONMEM7 CD).
My friend, a developer, said that It didn’t look like the problem of the
processors but of the compiler.
Because I’ve had fairly good relationship with AMD for long, I want to believe
he’s right.
Is anyone here who ‘ve met a similar problem?