RE: RE: Predicting body weight as a function of gestational age

From: [email protected] [mailto:[email protected]] On Behalf Of Sadler, Brian Sent: Thursday, November 11, 2010 10:35 AM To: [email protected] Subject: [NMusers] RE: Predicting body weight as a function of gestational age Thanks, Liping. The problem with the CDC and WHO data is that they are based on postnatal age (PNA). In my present model, gestational age (GA) was a better predictor of drug clearance and volume than PNA. Furthermore, body weight in the neonates appears to be better correlated with GA than PNA. Cheers... Brian From: Zhang, Liping (CD) [mailto:[email protected]] Sent: Thursday, November 11, 2010 10:23 AM To: Sadler, Brian; [email protected] Subject: RE: Predicting body weight as a function of gestational age Hi, Brian, I wonder why you want to model the body weight with age. Will the growth chart from CDC (based on children in US) or WHO (based on children in the world, and considering race), which contains statistics from a large pool and differentiated by gender be more helpful? for example, check http://www.cdc.gov/growthcharts/clinical_charts.htm#Summary. best regards, Liping From: [email protected] [mailto:[email protected]] On Behalf Of Sadler, Brian Sent: Thursday, November 11, 2010 10:03 AM To: [email protected] Subject: [NMusers] Predicting body weight as a function of gestational age Dear All, I am working on a PK model in neonates, infants, and children (postnatal ages 0-12 years). I am to the point of running simulations and was looking for a model to predict body weight as a function of gestational age. I could simply resample from the data used to construct the PK model or build a model based on the data in hand (n~200), but I was looking for a published model (based on a larger sample size) that might be used as a point of reference. As the relative difference between gestational age and postnatal age diminishes in older children models of body weight as a function of postnatal age for children >2 years old could also be useful. Thanks for any suggestions you might have. Cheers... Brian Brian M. Sadler, Ph.D. Sr Scientific Director ICON Development Solutions Internal Tel: 701-4860 External Tel: +1 (215) 616-4860 Mobile: +1 (919) 600-0889 Fax: +1 (215) 586-4048 Email: [email protected] Web: www.iconplc.com