RE: Predicting body weight as a function of gestational age
Hello,
You can use the CDC growth charts that can be found here:
http://www.cdc.gov/growthcharts/percentile_data_files.htm
The interesting files from the website are:
1. WTAGEINF [XLS - 34 KB]
http://www.cdc.gov/growthcharts/data/zscore/wtageinf.xls : birth to 36
months
2. WTAGE [XLS - 125 KB]
http://www.cdc.gov/growthcharts/data/zscore/wtage.xls : 2 to 20 years
I have struggled with the LMS parameter system in the CDC growth charts
to simulate variability. I have used some approximations in the past.
Does anyone have NONMEM code to simulate the variability in the weight
age relationship using the LMS parameters [median (M), the generalized
coefficient of variation (S), and the power in the Box-Cox
transformation (L)].
Thank-you,
Mahesh
Quoted reply history
From: [email protected] [mailto:[email protected]]
On Behalf Of Sadler, Brian
Sent: Thursday, November 11, 2010 10:03 AM
To: [email protected]
Subject: [NMusers] Predicting body weight as a function of gestational
age
Dear All,
I am working on a PK model in neonates, infants, and children (postnatal
ages 0-12 years). I am to the point of running simulations and was
looking for a model to predict body weight as a function of gestational
age. I could simply resample from the data used to construct the PK
model or build a model based on the data in hand (n~200), but I was
looking for a published model (based on a larger sample size) that might
be used as a point of reference. As the relative difference between
gestational age and postnatal age diminishes in older children models of
body weight as a function of postnatal age for children >2 years old
could also be useful.
Thanks for any suggestions you might have.
Cheers... Brian
Brian M. Sadler, Ph.D.
Sr Scientific Director
ICON Development Solutions
Internal Tel: 701-4860
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