RE: quality of SE estimate by IMP method
At this point the SE may be unreliable. Try using IMPMAP (and EONLY=1)
and see if that helps. Let it run for 20 iterations.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: www.icondevsolutions.com
Quoted reply history
________________________________
From: [email protected] [mailto:[email protected]]
On Behalf Of Ethan Wu
Sent: Thursday, September 16, 2010 11:46 AM
To: [email protected]
Subject: [NMusers] quality of SE estimate by IMP method
Dear uses,
I am using NM7 SAEM method for an analysis. As I learned from NM7
workshop, I used IMP method after SAEM to generate SE estimate.
In this case, at the end of SAEM iteration, OBJ was quite stable and
negative several thousand.
But, with IMP, after 5 iterations, Obj was up to positive several 10
to power of 7. Obj was decreasing during this 5 iterations.
My questions is, dose this mean SE estimate is not reliable? Should I
increase iterations of IMP?
Thank you.