Re: quality of SE estimate by IMP method
Hi Bob,
IMP/MAP also came back with pretty similar OBJ like IMP.
Below is the code I use, am I doing the wrong way?
$ESTIMATION METHOD=IMPMAP INTERACTION LAP EONLY=1 NOABORT NITER=20
PRINT=1 SIGL=6 NSIG=2 ISAMPLE=1000
Thank you.
Quoted reply history
________________________________
From: "Bauer, Robert" <[email protected]>
To: Ethan Wu <[email protected]>; [email protected]
Sent: Thu, September 16, 2010 2:26:07 PM
Subject: RE: [NMusers] quality of SE estimate by IMP method
Yes. Read the METHOD=CHAIN section in the intro712.pdf manual.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions
Tel:(215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: www.icondevsolutions.com
________________________________
From: Ethan Wu [mailto:[email protected]]
Sent: Thursday, September 16, 2010 12:19 PM
To: Bauer, Robert; [email protected]
Subject: Re: [NMusers] quality of SE estimate by IMP method
Hi Bob,
Is there a way to pick up from the last run with SAEM/IMP so to only run the
additional step IMPMAP?
Thank you.
________________________________
From: "Bauer, Robert" <[email protected]>
To: Ethan Wu <[email protected]>; [email protected]
Sent: Thu, September 16, 2010 12:12:28 PM
Subject: RE: [NMusers] quality of SE estimate by IMP method
At this point the SE may be unreliable. Try using IMPMAP (and EONLY=1) and see
if that helps. Let it run for 20 iterations.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions
Tel:(215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: www.icondevsolutions.com
________________________________
From: [email protected] [mailto:[email protected]] On
Behalf Of Ethan Wu
Sent: Thursday, September 16, 2010 11:46 AM
To: [email protected]
Subject: [NMusers] quality of SE estimate by IMP method
Dear uses,
I am using NM7 SAEM method for an analysis. As I learned from NM7 workshop, I
used IMP method after SAEM to generate SE estimate.
In this case, at the end of SAEM iteration, OBJ was quite stable and negative
several thousand.
But, with IMP, after 5 iterations, Obj was up to positive several 10 to power
of 7. Obj was decreasing during this 5 iterations.
My questions is, dose this mean SE estimate is not reliable? Should I
increase
iterations of IMP?
Thank you.