Fw: calculation of AUC
I second Bill's suggestion to work this out on your own for your specific
problem. This forum can help you with general questions and overall
approaches, but very specific queries like this are for you and your
colleagues to hash out.
----- Forwarded by Michael J Fossler/PharmRD/GSK on 03/20/2009 09:40 AM
-----
"Bill Bachman" <[email protected]>
Sent by: [email protected]
20-Mar-2009 09:17
To
"'Martin Bergstrand'" <[email protected]>, "'Ethan Wu'"
<[email protected]>, [email protected]
cc
Subject
RE: [NMusers] calculation of AUC
The easiest answer is to work it out. Do some simulations (without
variability) with multiple subjects with identical PK parameters BUT
different sampling times. Tabulate your AUCs and compare the results for
different sampling times!
Quoted reply history
From: [email protected] [mailto:[email protected]]
On Behalf Of Martin Bergstrand
Sent: Friday, March 20, 2009 8:45 AM
To: 'Ethan Wu'; [email protected]
Subject: RE: [NMusers] calculation of AUC
Dear Ethan,
You need to provide more information on how you plan to calculate AUC
otherwise the question can?t be answered. It is of course possible to
calculate the AUC without any influence of the sampling frequency. You
should be able to find examples of how to do this in the NMusers archive.
See for example the answer from Mats Karlsson in this thread (
http://nonmem.org/nonmem/nm/98apr032002.html).
Kind regards,
Martin Bergstrand, MSc, PhD student
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Department of Pharmaceutical Biosciences,
Uppsala University
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From: [email protected] [mailto:[email protected]]
On Behalf Of Ethan Wu
Sent: den 20 mars 2009 13:05
To: [email protected]
Subject: [NMusers] calculation of AUC
Hi all, to calculate AUC of one of the compartments using ADVAN6, if it is
a fixed time interval, will the AUC be influenced by the frequncy of
sampling of the dataset within this interval or not?
thanks
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