RE: calculation of AUC
The easiest answer is to work it out. Do some simulations (without
variability) with multiple subjects with identical PK parameters BUT
different sampling times. Tabulate your AUCs and compare the results for
different sampling times!
_____
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Martin Bergstrand
Sent: Friday, March 20, 2009 8:45 AM
To: 'Ethan Wu'; [email protected]
Subject: RE: [NMusers] calculation of AUC
Dear Ethan,
You need to provide more information on how you plan to calculate AUC
otherwise the question can't be answered. It is of course possible to
calculate the AUC without any influence of the sampling frequency. You
should be able to find examples of how to do this in the NMusers archive.
See for example the answer from Mats Karlsson in this thread
( http://nonmem.org/nonmem/nm/98apr032002.html).
Kind regards,
Martin Bergstrand, MSc, PhD student
-----------------------------------------------
Department of Pharmaceutical Biosciences,
Uppsala University
-----------------------------------------------
P.O. Box 591
SE-751 24 Uppsala
Sweden
-----------------------------------------------
<mailto:[email protected]> [email protected]
-----------------------------------------------
Work: +46 18 471 4639
Mobile: +46 709 994 396
Fax: +46 18 471 4003
From: [email protected] [mailto:[email protected]] On
Behalf Of Ethan Wu
Sent: den 20 mars 2009 13:05
To: [email protected]
Subject: [NMusers] calculation of AUC
Hi all, to calculate AUC of one of the compartments using ADVAN6, if it is a
fixed time interval, will the AUC be influenced by the frequncy of sampling
of the dataset within this interval or not?
thanks
_____
No viruses found in this incoming message
Scanned by iolo AntiVirus 1.5.6.4
http://www.iolo.com http://www.iolo.com/iav/iavpop3