RE: Very small P-Value for ETABAR

________________________________ From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Denney, William S. Sent: Thursday, November 13, 2008 10:41 AM To: Jian Xu; [email protected] Subject: RE: [NMusers] Very small P-Value for ETABAR Hi Jian, I would look for a covariate effect on that parameter. Thanks, Bill ________________________________ From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Jian Xu Sent: Thursday, November 13, 2008 10:16 AM To: [email protected] Subject: [NMusers] Very small P-Value for ETABAR Dear NMUSERS, A few years back, there was a discussion on the P-value for ETABAR. However, I am not sure how to appropriately handle very small P-value(s) for ETABAR situation during the development of a model. I need some clarifications to a few questions: 1: Should we just ignore this small P-Value warning? 2: Can we change IIV model to avoid small P-value for ETABAR? Or any other suggestions? 3: Does NONMEM make any assumptions on ETA distribution? This P-value for ETABAR really bugs me a lot. I look forward to seeing some input. Thank you and I appreicate your time and help. Jian Notice: This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station, New Jersey, USA 08889), and/or its affiliates (which may be known outside the United States as Merck Frosst, Merck Sharp & Dohme or MSD and in Japan, as Banyu - direct contact information for affiliates is available at http://www.merck.com/contact/contacts.html) that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system.