RE: Modeling a concentration curve with secondary peaks?
Xiaoli
You need to use a partitioned input function (e.g. two 'doses' outphased
by an adjustable time parameter and some partitioning fraction, also
adjustable), rather than increasing the compartimentality of your model.
Luis
---------------------------------------------------------------
Luis M. Pereira, Ph.D.
Assistant Professor, Biopharmaceutics and Pharmacokinetics
Massachusetts College of Pharmacy and Health Sciences
179 Longwood Ave, Boston, MA 02115
Phone: (617) 732-2905
Fax: (617) 732-2228
[EMAIL PROTECTED]
Quoted reply history
________________________________
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]
On Behalf Of Hou, Xiaoli Shirley (Shirley)
Sent: Friday, October 26, 2007 8:55 AM
To: [email protected]
Subject: [NMusers] Modeling a concentration curve with secondary peaks?
I need help for modeling a concentration curve with secondary peaks.
What models could I use? I tried two compartment models, but it couldn't
capture the secondary peaks. Suggestions or recommendations are highly
appreciated.
Thanks.
Dr. Xiaoli Shirley Hou
Senior Biometrician, Biometrics Research
Merck Research Labs WP53-120
West Point PA 19486
Phone (215) 652-7498 (first week of each month)
Phone (540) 381-9599 (rest of time)
Fax (215) 993-1835
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