RE: batches with different half-life - linear PK
Dear,
Just out of curiosity, why would a different batch cause a different
half life?
Are we talking about proteins/large molecules?
Malaz
Malaz A. AbuTarif,
B.Sc. (Pharmacy), Ph.D., G.C.P.M., M.B.A.
Principal Scientist, Schering- Plough Research Institute
2015 Galloping Hill Rd, K-15-2-2650
Kenilworth, NJ 07033
Tel: (908) 740-3835, Fax: (908) 740-2916
[EMAIL PROTECTED]
-----Original Message-----
Quoted reply history
From: [EMAIL PROTECTED]
[mailto:[EMAIL PROTECTED] On Behalf Of Bachman, William
(MYD)
Sent: Thursday, April 19, 2007 11:45 AM
To: [EMAIL PROTECTED]; [email protected]
Subject: RE: [NMusers] batches with different half-life - linear
PK
maybe I am missing something here, but, why don't you
parameterize your model in terms of half-life and put BATCH as a
covariate on half-life?
________________________________
From: [EMAIL PROTECTED]
[mailto:[EMAIL PROTECTED] On Behalf Of [EMAIL PROTECTED]
Sent: Thursday, April 19, 2007 10:54 AM
To: [email protected]
Subject: [NMusers] batches with different half-life - linear PK
Hello NONMEM Users,
Sometimes the same subjects receive the same drug from different
batches. Potentially, half-life can be different accross batches.
Theoretically, it is easy to model if PKis linear because NONMEM
superimposes single-dose processes to obtain predicted concentrations
for multiple doses. Does enyone know how to implement it in NONMEM?
Are there any classes or publications which can help?
Thanks!
Pavel
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