RE: batches with different half-life - linear PK
maybe I am missing something here, but, why don't you parameterize your
model in terms of half-life and put BATCH as a covariate on half-life?
Quoted reply history
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From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]
On Behalf Of [EMAIL PROTECTED]
Sent: Thursday, April 19, 2007 10:54 AM
To: [email protected]
Subject: [NMusers] batches with different half-life - linear PK
Hello NONMEM Users,
Sometimes the same subjects receive the same drug from different
batches. Potentially, half-life can be different accross batches.
Theoretically, it is easy to model if PKis linear because NONMEM
superimposes single-dose processes to obtain predicted concentrations
for multiple doses. Does enyone know how to implement it in NONMEM?
Are there any classes or publications which can help?
Thanks!
Pavel
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