batches with different half-life - linear PK

From: NONMEM Date: April 19, 2007 technical Source: mail-archive.com
Hello NONMEM Users, Sometimes the same subjects receive the same drug from different batches. Potentially, half-life can be different accross batches. Theoretically, it is easy to model if PKis linear because NONMEM superimposes single-dose processes to obtain predicted concentrations for multiple doses. Does enyone know how to implement it in NONMEM? Are there any classes or publications which can help? Thanks! Pavel
Apr 19, 2007 NONMEM batches with different half-life - linear PK
Apr 19, 2007 William Bachman RE: batches with different half-life - linear PK
Apr 19, 2007 Malaz Abutarif RE: batches with different half-life - linear PK
Apr 21, 2007 Alison Boeckmann Re: batches with different half-life - linear PK
Apr 22, 2007 Alison Boeckmann Re: batches with different half-life - linear PK